BMS-764459

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525461

CAS#: 1188407-45-5

Description: BMS-764459 is a novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).

Chemical Structure

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BMS-764459
CAS# 1188407-45-5
Instruction

Theoretical Analysis

MedKoo Cat#: 525461
Name: BMS-764459
CAS#: 1188407-45-5
Chemical Formula: C19H21F2N5O3
Exact Mass: 405.16
Molecular Weight: 405.406
Elemental Analysis: C, 56.29; H, 5.22; F, 9.37; N, 17.28; O, 11.84

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BMS-764459

IUPAC/Chemical Name: (S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile

InChi Key: PJMUNXORSUNUCV-OAHLLOKOSA-N

InChi Code: InChI=1S/C19H21F2N5O3/c1-10-6-14(11(2)23-17(10)29-19(20)21)25-16-18(27)26(8-13(7-22)24-16)15(9-28-3)12-4-5-12/h6,8,12,15,19H,4-5,9H2,1-3H3,(H,24,25)/t15-/m1/s1

SMILES Code: N#CC(N=C1NC2=CC(C)=C(OC(F)F)N=C2C)=CN([C@@H](C3CC3)COC)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 405.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Simic D, Euler C, Haines E, He A, Peden WM, Bunch RT, Sanderson T, Van Vleet T. MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459. Toxicology. 2013 Sep 15;311(3):169-77. doi: 10.1016/j.tox.2013.06.006. Epub 2013 Jul 2. PubMed PMID: 23831372.

2: Gater D, Macauley D. American Chemical Society--238th National Meeting & Exposition. Developments in medicinal chemistry: part 2. 16-20 August 2009, Washington DC, USA. IDrugs. 2009 Oct;12(10):608-11. PubMed PMID: 19790005.