WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525458

CAS#: 360794-85-0

Description: ORM-3819 is a novel selective and potent inhibitor of PDE III, promoting cardiac contractility through Ca(2+) sensitization.

Chemical Structure

CAS# 360794-85-0

Theoretical Analysis

MedKoo Cat#: 525458
Name: ORM-3819
CAS#: 360794-85-0
Chemical Formula: C19H19N5O5
Exact Mass: 397.1386
Molecular Weight: 397.391
Elemental Analysis: C, 57.43; H, 4.82; N, 17.62; O, 20.13

Price and Availability

Size Price Availability Quantity
5.0mg USD 240.0 2 Weeks
25.0mg USD 610.0 2 Weeks
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Synonym: ORM-3819

IUPAC/Chemical Name: (R)-6-{4-[N'-(4-Hydroxy-3-methoxy-2-nitro-benzylidene)-hydrazino]-phenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one


InChi Code: InChI=1S/C19H19N5O5/c1-11-9-16(26)22-23-17(11)12-3-6-14(7-4-12)21-20-10-13-5-8-15(25)19(29-2)18(13)24(27)28/h3-8,10-11,21,25H,9H2,1-2H3,(H,22,26)/b20-10+/t11-/m1/s1

SMILES Code: O=C1C[C@@H](C)C(C2=CC=C(N/N=C/C3=CC=C(O)C(OC)=C3[N+]([O-])=O)C=C2)=NN1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 397.391 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nagy L, Pollesello P, Haikala H, Végh Á, Sorsa T, Levijoki J, Szilágyi S, Édes I, Tóth A, Papp Z, Papp JG. ORM-3819 promotes cardiac contractility through Ca(2+) sensitization in combination with selective PDE III inhibition, a novel approach to inotropy. Eur J Pharmacol. 2016 Mar 15;775:120-9. doi: 10.1016/j.ejphar.2016.02.028. Epub 2016 Feb 9. PubMed PMID: 26872993.