BNS

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525457

CAS#: 1417440-37-9

Description: BNS is a potent and selective inhibitor of prolyl-hydroxylase 2 (PHD2).


Chemical Structure

img
BNS
CAS# 1417440-37-9

Theoretical Analysis

MedKoo Cat#: 525457
Name: BNS
CAS#: 1417440-37-9
Chemical Formula: C18H16N2O6S2
Exact Mass: 420.05
Molecular Weight: 420.454
Elemental Analysis: C, 51.42; H, 3.84; N, 6.66; O, 22.83; S, 15.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BNS

IUPAC/Chemical Name: 2,3-Dihydro-3-hydroxy-2-[[2-[(2-naphthalenylmethyl)sulfonyl]acetyl]imino]-4-thiazoleacetic acid

InChi Key: QNCNQHCDQMPPGD-HNENSFHCSA-N

InChi Code: InChI=1S/C18H16N2O6S2/c21-16(19-18-20(24)15(9-27-18)8-17(22)23)11-28(25,26)10-12-5-6-13-3-1-2-4-14(13)7-12/h1-7,9,24H,8,10-11H2,(H,22,23)/b19-18-

SMILES Code: O=C(O)CC1=CS/C(N1O)=N\C(CS(=O)(CC2=CC=C3C=CC=CC3=C2)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 420.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: An W, Han B, Li K, Akhtar S, Zhang Y, Zhang X, Sha X, Gao L. The protective study about alleviation of simvastatin on the damages of PEG-BNs in mice. Environ Toxicol Pharmacol. 2017 May 1;53:64-73. doi: 10.1016/j.etap.2017.04.021. [Epub ahead of print] PubMed PMID: 28505473.

2: Kalet AM, Doctor JN, Gennari JH, Phillips MH. Developing Bayesian networks from a dependency-layered ontology: a proof-of-concept in radiation oncology. Med Phys. 2017 May 13. doi: 10.1002/mp.12340. [Epub ahead of print] PubMed PMID: 28500765.

3: Glybochko PV, Rapoport LM, Bezrukov EA, Sirota ES, Martirosyan GA. The role of water-jet dissection in improving erectile function and urinary continence after nerve-sparing prostatectomy. Urologia. 2017 May 10:0. doi: 10.5301/uj.5000236. [Epub ahead of print] PubMed PMID: 28497446.

4: Li J, Fan N, Wang X, He Z. Cellular level evaluation and lysozyme adsorption regulation of bimodal nanoporous silica. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:509-517. doi: 10.1016/j.msec.2017.03.096. Epub 2017 Mar 15. PubMed PMID: 28482558.

5: Song D, Cheng Y, Li X, Wang F, Lu Z, Xiao X, Wang Y. Biogenic Nanoselenium Particles Effectively Attenuate Oxidative Stress-Induced Intestinal Epithelial Barrier Injury by Activating the Nrf2 Antioxidant Pathway. ACS Appl Mater Interfaces. 2017 May 3;9(17):14724-14740. doi: 10.1021/acsami.7b03377. Epub 2017 Apr 24. PubMed PMID: 28406025.

6: Belgian Neurological Society (BNS) and Belgian Dementia Council (BeDeCo) Joint Scientific Meeting University of Antwerp, Belgium, December 10th, 2016. Acta Neurol Belg. 2017 Jun;117(2):577-589. doi: 10.1007/s13760-017-0763-1. PubMed PMID: 28361291.

7: Liu Y, Duan W, Song W, Liu J, Ren C, Wu J, Liu D, Chen H. Red Emission B, N, S-co-Doped Carbon Dots for Colorimetric and Fluorescent Dual Mode Detection of Fe(3+) Ions in Complex Biological Fluids and Living Cells. ACS Appl Mater Interfaces. 2017 Apr 12;9(14):12663-12672. doi: 10.1021/acsami.6b15746. Epub 2017 Apr 3. PubMed PMID: 28339185.

8: Zhang Q, Yao Q. Dynamic Uncertain Causality Graph for Knowledge Representation and Reasoning: Utilization of Statistical Data and Domain Knowledge in Complex Cases. IEEE Trans Neural Netw Learn Syst. 2017 Mar 17. doi: 10.1109/TNNLS.2017.2673243. [Epub ahead of print] PubMed PMID: 28328514.

9: Cheng X, Qiu Y, Hou W, Ching WK. Integer programming-based method for observability of singleton attractors in Boolean networks. IET Syst Biol. 2017 Feb;11(1):30-35. doi: 10.1049/iet-syb.2016.0022. PubMed PMID: 28303791.

10: Luo Y, El Naqa I, McShan DL, Ray D, Lohse I, Matuszak MM, Owen D, Jolly S, Lawrence TS, Kong FS, Ten Haken RK. Unraveling biophysical interactions of radiation pneumonitis in non-small-cell lung cancer via Bayesian network analysis. Radiother Oncol. 2017 Apr;123(1):85-92. doi: 10.1016/j.radonc.2017.02.004. Epub 2017 Feb 22. PubMed PMID: 28237401; PubMed Central PMCID: PMC5386796.

11: Souza C, de Freitas LA, Maia Campos PM. Topical Formulation Containing Beeswax-Based Nanoparticles Improved In Vivo Skin Barrier Function. AAPS PharmSciTech. 2017 Feb 17. doi: 10.1208/s12249-017-0737-x. [Epub ahead of print] PubMed PMID: 28213845.

12: Imran S, Ko YB. A Continuous Object Boundary Detection and Tracking Scheme for Failure-Prone Sensor Networks. Sensors (Basel). 2017 Feb 13;17(2). pii: E361. doi: 10.3390/s17020361. PubMed PMID: 28208815; PubMed Central PMCID: PMC5335958.

13: Tuff T, Chrobak K. Septic olecranon and prepatellar bursitis in hockey players: a report of three cases. J Can Chiropr Assoc. 2016 Dec;60(4):305-310. PubMed PMID: 28065991; PubMed Central PMCID: PMC5178012.

14: Anbari MJ, Tabesh M, Roozbahani A. Risk assessment model to prioritize sewer pipes inspection in wastewater collection networks. J Environ Manage. 2017 Apr 1;190:91-101. doi: 10.1016/j.jenvman.2016.12.052. Epub 2016 Dec 29. PubMed PMID: 28040592.

15: Rezaianzadeh A, Sepandi M, Rahimikazerooni S. Assessment of Breast Cancer Risk in an Iranian Female Population Using Bayesian Networks with Varying Node Number. Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4913-4916. PubMed PMID: 28032495.

16: Kluck AS, Dallesasse S, English EM. Family Relations and Psychopathology: Examining Depressive and Bulimic Symptomatology. Child Psychiatry Hum Dev. 2016 Dec 26. doi: 10.1007/s10578-016-0705-9. [Epub ahead of print] PubMed PMID: 28025721.

17: Katsanos K, Al-Lamki SA, Parthipun A, Spiliopoulos S, Patel SD, Paraskevopoulos I, Zayed H, Diamantopoulos A. Peripheral Stent Thrombosis Leading to Acute Limb Ischemia and Major Amputation: Incidence and Risk Factors in the Aortoiliac and Femoropopliteal Arteries. Cardiovasc Intervent Radiol. 2017 Mar;40(3):351-359. doi: 10.1007/s00270-016-1513-0. Epub 2016 Dec 5. PubMed PMID: 27921154; PubMed Central PMCID: PMC5288432.

18: Cohain A, Divaraniya AA, Zhu K, Scarpa JR, Kasarskis A, Zhu J, Chang R, Dudley JT, Schadt EE. EXPLORING THE REPRODUCIBILITY OF PROBABILISTIC CAUSAL MOLECULAR NETWORK MODELS. Pac Symp Biocomput. 2016;22:120-131. PubMed PMID: 27896968; PubMed Central PMCID: PMC5161348.

19: Lin Z, Cantone J, Lu H, Nowicka-Sans B, Protack T, Yuan T, Yang H, Liu Z, Drexler D, Regueiro-Ren A, Meanwell NA, Cockett M, Krystal M, Lataillade M, Dicker IB. Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors. PLoS Pathog. 2016 Nov 28;12(11):e1005990. doi: 10.1371/journal.ppat.1005990. eCollection 2016 Nov. PubMed PMID: 27893830; PubMed Central PMCID: PMC5125710.

20: Langdahl JH, Frederiksen AL, Nguyen N, Brusgaard K, Juhl CB. Boucher Neuhäuser Syndrome - A rare cause of inherited hypogonadotropic hypogonadism. A case of two adult siblings with two novel mutations in PNPLA6. Eur J Med Genet. 2017 Feb;60(2):105-109. doi: 10.1016/j.ejmg.2016.11.003. Epub 2016 Nov 16. PubMed PMID: 27866050.