HPB

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525453

CAS#: 1800066-24-3

Description: HPB is a selective inhibitor of HDAC6 deacetylase.


Chemical Structure

img
HPB
CAS# 1800066-24-3

Theoretical Analysis

MedKoo Cat#: 525453
Name: HPB
CAS#: 1800066-24-3
Chemical Formula: C18H20N2O4
Exact Mass: 328.14
Molecular Weight: 328.370
Elemental Analysis: C, 65.84; H, 6.14; N, 8.53; O, 19.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: HPB

IUPAC/Chemical Name: N-Hydroxy-4-((N-(2-hydroxyethyl)-2-phenylacetamido)methyl)benzamide

InChi Key: GTFAUKGKYICUDS-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H20N2O4/c21-11-10-20(17(22)12-14-4-2-1-3-5-14)13-15-6-8-16(9-7-15)18(23)19-24/h1-9,21,24H,10-13H2,(H,19,23)

SMILES Code: O=C(NO)C1=CC=C(CN(CCO)C(CC2=CC=CC=C2)=O)C=C1

Appearance: Color: white to off-white Form: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 328.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Jiménez-Romero C, Cambra F, Caso O, Manrique A, Calvo J, Marcacuzco A, Rioja P, Lora D, Justo I. Octogenarian liver grafts: Is their use for transplant currently justified? World J Gastroenterol. 2017 May 7;23(17):3099-3110. doi: 10.3748/wjg.v23.i17.3099. PubMed PMID: 28533667; PubMed Central PMCID: PMC5423047.

2: Aahlin EK, Olsen F, Uleberg B, Jacobsen B, Lassen K. Major postoperative complications are associated with impaired long-term survival after upper abdominal cancer surgery: A complete national cohort study. Clin Nutr ESPEN. 2016 Apr;12:e40. doi: 10.1016/j.clnesp.2016.02.033. Epub 2016 Apr 1. PubMed PMID: 28531696.

3: Cochran A, Raub K, Kirks RC, Barnes TE, Murphy K, Iannitti DA, Martinie JB, Vrochides D. Novel use of redcap to develop a platform for tracking ERAS compliance and displaying predictive analytics. Clin Nutr ESPEN. 2016 Apr;12:e34. doi: 10.1016/j.clnesp.2016.02.016. Epub 2016 Apr 1. PubMed PMID: 28531678.

4: Cochran A, Murphy K, Kirks RC, Barnes TE, Iannitti DA, Martinie JB, Vrochides D. Prediction of postoperative outcomes after open major hepatectomy: Developing customised, procedure-specific predictive risk metrics. Clin Nutr ESPEN. 2016 Apr;12:e33. doi: 10.1016/j.clnesp.2016.02.013. Epub 2016 Apr 1. PubMed PMID: 28531676.

5: Cochran A, Murphy K, Kirks RC, Barnes TE, Iannitti DA, Martinie JB, Vrochides D. Developing and validating predictive customised risk metrics to predict postoperative outcomes after pancreaticoduodenectomy. Clin Nutr ESPEN. 2016 Apr;12:e32. doi: 10.1016/j.clnesp.2016.02.009. Epub 2016 Apr 1. PubMed PMID: 28531672.

6: Kelgiorgi D, Dervenis C. Pancreatic neuroendocrine tumors: the basics, the gray zone, and the target. F1000Res. 2017 May 10;6:663. doi: 10.12688/f1000research.10188.1. eCollection 2017. Review. PubMed PMID: 28529726; PubMed Central PMCID: PMC5428491.

7: Adair A. Bariatric surgery for the obese patients undergoing liver transplantation: the case for. HPB (Oxford). 2017 May 17. pii: S1365-182X(17)30558-0. doi: 10.1016/j.hpb.2017.02.446. [Epub ahead of print] PubMed PMID: 28528269.

8: Blakely K, Karanicolas PJ, Wright FC, Gotlib Conn L. Optimistic honesty: understanding surgeon and patient perspectives on hopeful communication in pancreatic cancer care. HPB (Oxford). 2017 May 17. pii: S1365-182X(17)30557-9. doi: 10.1016/j.hpb.2017.04.001. [Epub ahead of print] PubMed PMID: 28528268.

9: Clarke CN, Choi H, Hou P, Davis CH, Ma J, Rashid A, Vauthey JN, Aloia TA. Using MRI to non-invasively and accurately quantify preoperative hepatic steatosis. HPB (Oxford). 2017 May 17. pii: S1365-182X(17)30570-1. doi: 10.1016/j.hpb.2017.04.009. [Epub ahead of print] PubMed PMID: 28528267.

10: Petrushnko W, Gundara JS, De Reuver PR, O'Grady G, Samra JS, Mittal A. Response to Altman et al. HPB (Oxford). 2017 May 17. pii: S1365-182X(17)30544-0. doi: 10.1016/j.hpb.2017.03.008. [Epub ahead of print] PubMed PMID: 28528266.

11: Gordon-Weeks A, Samarendra H, de Bono J, Soonawalla Z, Silva M. Surgeons opinions of legal practice in bile duct injury following cholecystectomy. HPB (Oxford). 2017 May 17. pii: S1365-182X(17)30573-7. doi: 10.1016/j.hpb.2017.04.012. [Epub ahead of print] PubMed PMID: 28526400.

12: Halle-Smith JM, Vinuela E, Brown RM, Hodson J, Zia Z, Bramhall SR, Marudanayagam R, Sutcliffe RP, Mirza DF, Muiesan P, Isaac J, Roberts KJ. A comparative study of risk factors for pancreatic fistula after pancreatoduodenectomy or distal pancreatectomy. HPB (Oxford). 2017 May 15. pii: S1365-182X(17)30574-9. doi: 10.1016/j.hpb.2017.04.013. [Epub ahead of print] PubMed PMID: 28522378.

13: Krige J, Nicol A, Navsaria P. Managing grade 5 pancreatic injuries-Think smart, act smart, and call in the pancreatic cavalry early. J Trauma Acute Care Surg. 2017 Jun;82(6):1187-1188. doi: 10.1097/TA.0000000000001459. PubMed PMID: 28520690.

14: Graversen M, Detlefsen S, Bjerregaard JK, Pfeiffer P, Mortensen MB. Peritoneal metastasis from pancreatic cancer treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Clin Exp Metastasis. 2017 May 17. doi: 10.1007/s10585-017-9849-7. [Epub ahead of print] PubMed PMID: 28516306.

15: Frigerio I, Regi P, Giardino A, Scopelliti F, Girelli R, Bassi C, Gobbo S, Martini PT, Capelli P, D'Onofrio M, Malleo G, Maggino L, Viviani E, Butturini G. Downstaging in Stage IV Pancreatic Cancer: A New Population Eligible for Surgery? Ann Surg Oncol. 2017 May 17. doi: 10.1245/s10434-017-5885-4. [Epub ahead of print] PubMed PMID: 28516291.

16: Sureka B, Rastogi A, Bihari C, Bharathy KGS, Sood V, Alam S. Imaging in ductal plate malformations. Indian J Radiol Imaging. 2017 Jan-Mar;27(1):6-12. doi: 10.4103/0971-3026.202966. PubMed PMID: 28515578; PubMed Central PMCID: PMC5385778.

17: Feng X, Su Y, Zheng S, Xia F, Ma K, Yan J, Li X, Tang W, Wang S, Bie P, Dong J. A double blinded prospective randomized trial comparing the effect of anatomic versus non-anatomic resection on hepatocellular carcinoma recurrence. HPB (Oxford). 2017 May 9. pii: S1365-182X(17)30571-3. doi: 10.1016/j.hpb.2017.04.010. [Epub ahead of print] PubMed PMID: 28499749.

18: Azoulay D, Bhangui P, Pascal G, Salloum C, Andreani P, Ichai P, Saliba F, Lim C. The impact of expanded indications on short-term outcomes for resection of malignant tumours of the liver over a 30 year period. HPB (Oxford). 2017 May 8. pii: S1365-182X(17)30566-X. doi: 10.1016/j.hpb.2017.04.005. [Epub ahead of print] PubMed PMID: 28495439.

19: Bezinover D, Reeder E, Aziz F, Saner F, McQuillan P, Kadry Z, Riley T, Guvakov D, Janicki PK. African Americans have a lower prevalence of portal vein thrombosis at the time of liver transplantation. HPB (Oxford). 2017 May 8. pii: S1365-182X(17)30560-9. doi: 10.1016/j.hpb.2017.04.002. [Epub ahead of print] PubMed PMID: 28495438.

20: Lordan JT, Roberts JK, Hodson J, Isaac J, Muiesan P, Mirza DF, Marudanayagam R, Sutcliffe RP. Case-controlled study comparing peri-operative and cancer-related outcomes after major hepatectomy and parenchymal sparing hepatectomy for metastatic colorectal cancer. HPB (Oxford). 2017 May 9. pii: S1365-182X(17)30568-3. doi: 10.1016/j.hpb.2017.04.007. [Epub ahead of print] PubMed PMID: 28495437.