U75302

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532851

CAS#: 119477-85-9

Description: U75302 is a thymosin beta-4 (TB4) receptor antagonist with a Ki of 159 nM on guinea pig lung membranes.


Price and Availability

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U75302 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532851
Name: U75302
CAS#: 119477-85-9
Chemical Formula: C22H35NO3
Exact Mass: 361.2617
Molecular Weight: 361.53
Elemental Analysis: C, 73.09; H, 9.76; N, 3.87; O, 13.28


Synonym: U75302, U 75302, U-75302

IUPAC/Chemical Name: (5S)-6-[6-[(1E,3R,5Z)-3-hydroxyundeca-1,5-dienyl]pyridin-2-yl]hexane-1,5-diol

InChi Key: JNBOAUIJLDEICX-LJCAKPRGSA-N

InChi Code: InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-13-21(25)16-15-19-11-10-12-20(23-19)18-22(26)14-8-9-17-24/h6-7,10-12,15-16,21-22,24-26H,2-5,8-9,13-14,17-18H2,1H3/b7-6-,16-15+/t21-,22+/m1/s1

SMILES Code: OCCCC[C@H](O)CC1=NC(/C=C/[C@H](O)C/C=C\CCCCC)=CC=C1


Technical Data

Appearance:
White to off-white crystalline powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1. Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. Journal of Pharmacology and Experimental Therapeutics 255, 565-571 (1990).

2. Lin, A.H.,Morris, J.,Wishka, D.G., et al. Novel molecules that antagonize leukotriene B4 binding to neutrophils. Annals of the New York Academy of Sciences 524, 196-200 (1988).

3. Wang, S.,Gustafson, E.,Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. The Journal of Biological Chemisty 275, 40686-40694 (2000).