U69593 HCl

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MedKoo CAT#: 532850

CAS#: U69593 HCl

Description: U69593 is a a selective KOR-1 (κ1-opioid receptor) agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.

Chemical Structure

U69593 HCl
CAS# U69593 HCl

Theoretical Analysis

MedKoo Cat#: 532850
Name: U69593 HCl
CAS#: U69593 HCl
Chemical Formula: C22H33ClN2O2
Exact Mass: 0.00
Molecular Weight: 392.968
Elemental Analysis: C, 67.24; H, 8.46; Cl, 9.02; N, 7.13; O, 8.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Related CAS #: 1313288-99-1 (free base)   96744-75-1 (free base)   U69593 HCl   U-69593 Maleate    

Synonym: U69593, U 69593, U-69593; U69593 HCl; U69593 hydrochloride.

IUPAC/Chemical Name: N-methyl-2-phenyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide hydrochloride


InChi Code: InChI=1S/C22H32N2O2.ClH/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24;/h2-4,8-9,19-20H,5-7,10-17H2,1H3;1H/t19-,20-,22-;/m0./s1

SMILES Code: O=C(N(C)[C@@H](CC1)[C@@H](N2CCCC2)C[C@@]31CCCO3)CC4=CC=CC=C4.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 392.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Escobar Adel P, Cornejo FA, Andrés ME, Fuentealba JA. Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats. Neurochem Int. 2012 Mar;60(4):344-9. doi: 10.1016/j.neuint.2012.01.014. Epub 2012 Jan 28. PubMed PMID: 22306346.

2: Morani AS, Kivell B, Prisinzano TE, Schenk S. Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats. Pharmacol Biochem Behav. 2009 Dec;94(2):244-9. doi: 10.1016/j.pbb.2009.09.002. Epub 2009 Sep 10. PubMed PMID: 19747933; PubMed Central PMCID: PMC3021564.

3: Perreault ML, Graham D, Scattolon S, Wang Y, Szechtman H, Foster JA. Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats. Psychopharmacology (Berl). 2007 Nov;194(4):485-96. Epub 2007 Jul 10. PubMed PMID: 17619861.