KIN1408 | CAS#1903800-11-2

KIN1408
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525443

CAS#: 1903800-11-2

Description: KIN1408 is an inducer of cellular transcription of innate immune genes in a MAVS- and IRF3-dependent manner, exhibiting broad-spectrum anti-viral activity.

Chemical Structure

KIN1408

CAS# 1903800-11-2

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 525443
Name: KIN1408
CAS#: 1903800-11-2
Chemical Formula: C25H19F2N3O3S
Exact Mass: 479.11
Molecular Weight: 479.502
Elemental Analysis: C, 62.62; H, 3.99; F, 7.92; N, 8.76; O, 10.01; S, 6.69

Price and Availability

Size	Price	Availability
10mg	USD 350	2 Weeks
25mg	USD 650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: KIN1408

IUPAC/Chemical Name: 7-((4-(Difluoromethoxy)phenyl)(5-methoxybenzo[d]thiazol-2-ylamino)methyl)quinolin-8-ol

InChi Key: YSGBFDHVEQJPPX-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H19F2N3O3S/c1-32-17-9-11-20-19(13-17)29-25(34-20)30-21(15-4-7-16(8-5-15)33-24(26)27)18-10-6-14-3-2-12-28-22(14)23(18)31/h2-13,21,24,31H,1H3,(H,29,30)

SMILES Code: OC1=C2N=CC=CC2=CC=C1C(C3=CC=C(OC(F)F)C=C3)NC4=NC5=CC(OC)=CC=C5S4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	KIN1408 is an agonist of the RIG-1-like receptor (RLR) pathway and exhibits a broad-spectrum antiviral activity.
In vitro activity:	Treatment of cells with 5 μM KIN1408 was sufficient to cause a 1.5-log-unit decrease in the number of infectious virus particles compared to that achieved with treatment with DMSO at 96 h postinfection (Fig. 7C). Reference: J Virol. 2015 Dec 16;90(5):2372-87. https://pubmed.ncbi.nlm.nih.gov/26676770/
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.5	71.95

Preparing Stock Solutions

The following data is based on the product molecular weight 479.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Pattabhi S, Wilkins CR, Dong R, Knoll ML, Posakony J, Kaiser S, Mire CE, Wang ML, Ireton RC, Geisbert TW, Bedard KM, Iadonato SP, Loo YM, Gale M Jr. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol. 2015 Dec 16;90(5):2372-87. doi: 10.1128/JVI.02202-15. PMID: 26676770; PMCID: PMC4810700.
In vitro protocol:	1. Pattabhi S, Wilkins CR, Dong R, Knoll ML, Posakony J, Kaiser S, Mire CE, Wang ML, Ireton RC, Geisbert TW, Bedard KM, Iadonato SP, Loo YM, Gale M Jr. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol. 2015 Dec 16;90(5):2372-87. doi: 10.1128/JVI.02202-15. PMID: 26676770; PMCID: PMC4810700.
In vivo protocol:	TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Your view history

KIN1408 featured