Aza-THIP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525424

CAS#: 654666-65-6

Description: Aza-THIP is a novel selective GABA-C antagonist.

Chemical Structure

img
Aza-THIP
CAS# 654666-65-6
Instruction

Theoretical Analysis

MedKoo Cat#: 525424
Name: Aza-THIP
CAS#: 654666-65-6
Chemical Formula: C6H9N3O
Exact Mass: 139.07
Molecular Weight: 139.158
Elemental Analysis: C, 51.79; H, 6.52; N, 30.20; O, 11.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Aza-THIP

IUPAC/Chemical Name: 4,5,6,7-Tetrahydropyrazolo[5,4-c]pyridin-3-ol

InChi Key: UPMMUUFLHUEUKP-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H9N3O/c10-6-4-1-2-7-3-5(4)8-9-6/h7H,1-3H2,(H2,8,9,10)

SMILES Code: OC1=NNC2=C1CCNC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 139.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Valembois S, Krall J, Frølund B, Steffansen B. Imidazole-4-acetic acid, a new lead structure for interaction with the taurine transporter in outer blood-retinal barrier cells. Eur J Pharm Sci. 2017 May 30;103:77-84. doi: 10.1016/j.ejps.2017.02.041. Epub 2017 Mar 1. PubMed PMID: 28259832.

2: Johnston GA, Chebib M, Hanrahan JR, Mewett KN. Neurochemicals for the investigation of GABA(C) receptors. Neurochem Res. 2010 Dec;35(12):1970-7. doi: 10.1007/s11064-010-0271-7. Epub 2010 Oct 21. Review. PubMed PMID: 20963487.

3: Krehan D, Frølund B, Ebert B, Nielsen B, Krogsgaard-Larsen P, Johnston GA, Chebib M. Aza-THIP and related analogues of THIP as GABA C antagonists. Bioorg Med Chem. 2003 Nov 17;11(23):4891-6. PubMed PMID: 14604650.

4: Johnston GA, Chebib M, Hanrahan JR, Mewett KN. GABA(C) receptors as drug targets. Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):260-8. Review. PubMed PMID: 12871036.