Propacetamol Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525420

CAS#: 66532-86-3

Description: Propacetamol Hydrochloride is a prodrug of paracetamol (PCM), being effectively used to treat fever and pain.

Chemical Structure

Propacetamol Hydrochloride
CAS# 66532-86-3

Theoretical Analysis

MedKoo Cat#: 525420
Name: Propacetamol Hydrochloride
CAS#: 66532-86-3
Chemical Formula: C14H21ClN2O3
Exact Mass: 300.1241
Molecular Weight: 300.783
Elemental Analysis: C, 55.91; H, 7.04; Cl, 11.79; N, 9.31; O, 15.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Propacetamol Hydrochloride

IUPAC/Chemical Name: (4-Acetamidophenyl) 2-(diethylamino)acetate hydrochloride


InChi Code: InChI=1S/C14H20N2O3.ClH/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17;/h6-9H,4-5,10H2,1-3H3,(H,15,17);1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 300.783 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: Zhang A, Jiang T, Luo Y, Zheng Z, Shi X, Xiao Z, Fang Y. Efficacy of intravenous propacetamol hydrochloride in the treatment of an acute attack of migraine. Eur J Intern Med. 2014 Sep;25(7):629-32. doi: 10.1016/j.ejim.2014.06.007. Epub 2014 Jul 5. PubMed PMID: 25002083.

2: Rodenas V, García MS, Sánchez-Pedreño C, Albero MI. Simultaneous determination of propacetamol and paracetamol by derivative spectrophotometry. Talanta. 2000 Jun 30;52(3):517-23. PubMed PMID: 18968011.

3: Barcia E, Martin A, Azuara ML, Negro S. Influence of medium and temperature on the hydrolysis kinetics of propacetamol hydrochloride: determination using derivative spectrophotometry. Chem Pharm Bull (Tokyo). 2005 Mar;53(3):277-80. PubMed PMID: 15744097.

4: Ma EL, Wang XR, Jiang ZM, Cui Y, Wang R, Liu J. [A randomized, double blind, and controlled clinical trial of the non-addictive propacetamol in postoperative analgesia]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Jun;25(3):329-32. Chinese. PubMed PMID: 12905750.

5: Gielen K, Goossens A. Occupational allergic contact dermatitis from drugs in healthcare workers. Contact Dermatitis. 2001 Nov;45(5):273-9. PubMed PMID: 11722486.

6: Marazova K, Klouchek E, Popov A, Frangov P, Di Massa A. Gastroprotective effect of propacetamol against cold/restraint stress ulcers in rats. Minerva Anestesiol. 1999 Jul-Aug;65(7-8):515-20. PubMed PMID: 10479838.

7: Mom T, Bazin JE, Commun F, Dubray C, Eschalier A, Derbal C, Avan P, Gilain L. Assessment of postoperative pain after laryngeal surgery for cancer. Arch Otolaryngol Head Neck Surg. 1998 Jul;124(7):794-8. PubMed PMID: 9677116.

8: De Coninck AL, Van Strubarq AS, Pipeleers-Marichal MA, Huyghens LP, Suys ET, Roseeuw DI. Acute generalized exanthematous pustulosis induced by paracetamol. A case with severe hemodynamic disturbances. Dermatology. 1996;193(4):338-41. Review. PubMed PMID: 8993963.

9: Monrigal C, Jacob JP, Granry JC. [Comparison of the analgesic efficacy of nalbuphine and its combination with propacetamol during the immediate postoperative period in gynecologic-obstetric surgery]. Ann Fr Anesth Reanim. 1994;13(2):153-7. French. PubMed PMID: 7818196.