WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525390

CAS#: 518357-51-2

Description: 3-MATIDA is a metabotropic glutamate I (mGlu1) receptor antagonist.

Price and Availability




3-MATIDA is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 525390
Name: 3-MATIDA
CAS#: 518357-51-2
Chemical Formula: C15H16N2O8S2
Exact Mass: 416.0348
Molecular Weight: 416.419
Elemental Analysis: C, 43.27; H, 3.87; N, 6.73; O, 30.74; S, 15.40

Synonym: 3-MATIDA

IUPAC/Chemical Name: 3-Methyl-aminothiophene dicarboxylic acid; 5-(Amino(carboxy)methyl)-4-methylthiophene-2-carboxylic acid


InChi Code: InChI=1S/C8H9NO4S.C7H7NO4S/c1-3-2-4(7(10)11)14-6(3)5(9)8(12)13;1-8-4-3(6(9)10)2-13-5(4)7(11)12/h2,5H,9H2,1H3,(H,10,11)(H,12,13);2,8H,1H3,(H,9,10)(H,11,12)

SMILES Code: CNC1=C(C(O)=O)SC=C1C(O)=O.O=C(C2=CC(C)=C(C(N)C(O)=O)S2)O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


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7: Meli E, Baronti R, Pangallo M, Picca R, Moroni F, Pellegrini-Giampietro DE. Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures. Neuropharmacology. 2005;49 Suppl 1:80-8. PubMed PMID: 16023154.

8: Costantino G, Marinozzi M, Camaioni E, Natalini B, Sarichelou I, Micheli F, Cavanni P, Faedo S, Noe C, Moroni F, Pellicciari R. Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist. Farmaco. 2004 Feb;59(2):93-9. PubMed PMID: 14871500.

9: Cozzi A, Meli E, Carlà V, Pellicciari R, Moroni F, Pellegrini-Giampietro DE. Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? Neuropharmacology. 2002 Aug;43(2):119-30. PubMed PMID: 12213266.

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