CFMTI
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525385

CAS#: 864864-17-5

Description: CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist

Chemical Structure

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CFMTI
CAS# 864864-17-5
Instruction

Theoretical Analysis

MedKoo Cat#: 525385
Name: CFMTI
CAS#: 864864-17-5
Chemical Formula: C19H16FN5O
Exact Mass: 349.13
Molecular Weight: 349.369
Elemental Analysis: C, 65.32; H, 4.62; F, 5.44; N, 20.05; O, 4.58

Price and Availability

Size Price Availability Quantity
100mg USD 1350
200mg USD 1950
500mg USD 2650
1g USD 3450
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Synonym: CFMTI

IUPAC/Chemical Name: 2-Cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one

InChi Key: XZBFQWRAIYRPPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16FN5O/c1-11-17(22-23-25(11)16-3-2-8-21-18(16)20)12-4-7-15-13(9-12)10-24(19(15)26)14-5-6-14/h2-4,7-9,14H,5-6,10H2,1H3

SMILES Code: O=C1N(C2CC2)CC3=C1C=CC(C4=C(C)N(C5=CC=CN=C5F)N=N4)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 349.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Suzuki G, Satow A, Ohta H. Effect of CFMTI, an allosteric metabotropic glutamate receptor 1 antagonist with antipsychotic activity, on Fos expression in regions of the brain related to schizophrenia. Neuroscience. 2010 Jul 14;168(3):787-96. doi: 10.1016/j.neuroscience.2010.04.016. Epub 2010 Apr 18. PubMed PMID: 20399255.

2: Hikichi H, Nishino M, Fukushima M, Satow A, Maehara S, Kawamoto H, Ohta H. Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice. Eur J Pharmacol. 2010 Aug 10;639(1-3):99-105. doi: 10.1016/j.ejphar.2010.03.046. Epub 2010 Apr 2. PubMed PMID: 20371235.

3: Satow A, Suzuki G, Maehara S, Hikichi H, Murai T, Murai T, Kawagoe-Takaki H, Hata M, Ito S, Ozaki S, Kawamoto H, Ohta H. Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dih ydro-1H-isoindol-1-one. J Pharmacol Exp Ther. 2009 Jul;330(1):179-90. doi: 10.1124/jpet.109.151118. Epub 2009 Apr 9. PubMed PMID: 19359526.