WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525367
CAS#: 78028-01-0
Description: CAY10397 is a selective inhibitor of 15-hydroxy PGDH, significantly suppressing endogenous 11-oxo-ETE production with a corresponding increase in 11(R)-HETE.
MedKoo Cat#: 525367
Name: CAY10397
CAS#: 78028-01-0
Chemical Formula: C17H16N2O5
Exact Mass: 328.1059
Molecular Weight: 328.324
Elemental Analysis: C, 62.19; H, 4.91; N, 8.53; O, 24.36
This product is not in stock, which may be available by custom synthesis.
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Synonym: CAY10397
IUPAC/Chemical Name: 5-[[4-(Ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid
InChi Key: YYBSDOZYJSGLTH-VHEBQXMUSA-N
InChi Code: InChI=1S/C17H16N2O5/c1-2-24-17(23)11-3-5-13(6-4-11)18-19-14-7-8-15(20)12(9-14)10-16(21)22/h3-9,20H,2,10H2,1H3,(H,21,22)/b19-18+
SMILES Code: O=C(O)CC1=CC(/N=N/C2=CC=C(C(OCC)=O)C=C2)=CC=C1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 328.324 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Liu X, Zhang S, Arora JS, Snyder NW, Shah SJ, Blair IA. 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid. Chem Res Toxicol. 2011 Dec 19;24(12):2227-36. doi: 10.1021/tx200336f. Epub 2011 Sep 30. PubMed PMID: 21916491; PubMed Central PMCID: PMC3242474.
2: Wei C, Zhu P, Shah SJ, Blair IA. 15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation. Mol Pharmacol. 2009 Sep;76(3):516-25. doi: 10.1124/mol.109.057489. Epub 2009 Jun 17. PubMed PMID: 19535459; PubMed Central PMCID: PMC2730384.
