NC043

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525346

CAS#: 1053172-87-4

Description: NC043 is a novel inhibitor of Wnt/β-catenin signaling, binds directly to CARF through forming a covalent bond with the Cys-516 residue of CARF.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

NC043 is not in stock. We temporally do not accept order of custom synthesis for this product since raw material is not available. We will list price if this product is in stock in the future.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525346
Name: NC043
CAS#: 1053172-87-4
Chemical Formula: C22H30O4
Exact Mass: 358.2144
Molecular Weight: 358.478
Elemental Analysis: C, 73.71; H, 8.44; O, 17.85


Synonym: NC043; NC-043; NC 043.

IUPAC/Chemical Name: 15-Oxospiramilactone

InChi Key: RCPPZYXWUAJXMA-KGYWYPJXSA-N

InChi Code: InChI=1S/C22H30O4/c1-13-14-4-7-22(19(13)25)16(10-14)21-6-3-5-20(2,15(21)11-17(22)23)8-9-26-12-18(21)24/h14-17,23H,1,3-12H2,2H3/t14-,15+,16-,17+,20-,21-,22+/m0/s1

SMILES Code: C=C([C@@H]1C2)C([C@]([C@H](O)C3)(CC1)[C@@H]2[C@@]4(C5=O)[C@H]3[C@@](CCOC5)(C)CCC4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: He X, Zhang W, Yan C, Nie F, Li C, Liu X, Fei C, Li S, Song X, Jia Y, Zeng R, Wu D, Pan W, Hao X, Li L. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discov. 2017 Jan 31;3:17003. doi: 10.1038/celldisc.2017.3. eCollection 2017. PubMed PMID: 28417011; PubMed Central PMCID: PMC5387711.

2: Wang W, Liu H, Wang S, Hao X, Li L. A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res. 2011 May;21(5):730-40. doi: 10.1038/cr.2011.30. Epub 2011 Feb 15. PubMed PMID: 21321609; PubMed Central PMCID: PMC3203668.