AM4113
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525320

CAS#: 614726-85-1

Description: AM4113 is a cannabinoid receptor 1 (CB1)-selective antagonist.


Chemical Structure

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AM4113
CAS# 614726-85-1

Theoretical Analysis

MedKoo Cat#: 525320
Name: AM4113
CAS#: 614726-85-1
Chemical Formula: C17H12Cl3N3O
Exact Mass: 379.0046
Molecular Weight: 380.653
Elemental Analysis: C, 53.64; H, 3.18; Cl, 27.94; N, 11.04; O, 4.20

Price and Availability

Size Price Availability Quantity
10.0mg USD 305.0 2 Weeks
50.0mg USD 975.0 2 Weeks
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Synonym: AM4113

IUPAC/Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide

InChi Key: BBUKVPCUOHFAQN-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H12Cl3N3O/c1-9-15(17(21)24)22-23(14-7-6-12(19)8-13(14)20)16(9)10-2-4-11(18)5-3-10/h2-8H,1H3,(H2,21,24)

SMILES Code: O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(Cl)C=C3)=C1C)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 380.653 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gueye AB, Pryslawsky Y, Trigo JM, Poulia N, Delis F, Antoniou K, Loureiro M, Laviolette SR, Vemuri K, Makriyannis A, Le Foll B. The CB1 Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability. Int J Neuropsychopharmacol. 2016 Dec 30;19(12). pii: pyw068. doi: 10.1093/ijnp/pyw068. Print 2016 Dec. PubMed PMID: 27493155; PubMed Central PMCID: PMC5203757.

2: Schindler CW, Redhi GH, Vemuri K, Makriyannis A, Le Foll B, Bergman J, Goldberg SR, Justinova Z. Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys. Neuropsychopharmacology. 2016 Aug;41(9):2283-93. doi: 10.1038/npp.2016.27. Epub 2016 Feb 18. PubMed PMID: 26888056; PubMed Central PMCID: PMC4946059.

3: Tai S, Nikas SP, Shukla VG, Vemuri K, Makriyannis A, Järbe TU. Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist. Psychopharmacology (Berl). 2015 Aug;232(15):2751-61. doi: 10.1007/s00213-015-3907-0. Epub 2015 Mar 15. PubMed PMID: 25772338; PubMed Central PMCID: PMC4504748.

4: Raver SM, Keller A. Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms. Neuropharmacology. 2014 Nov;86:161-73. doi: 10.1016/j.neuropharm.2014.07.006. Epub 2014 Jul 15. PubMed PMID: 25036610; PubMed Central PMCID: PMC4188721.

5: Randall PA, Lee CA, Nunes EJ, Yohn SE, Nowak V, Khan B, Shah P, Pandit S, Vemuri VK, Makriyannis A, Baqi Y, Müller CE, Correa M, Salamone JD. The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs. PLoS One. 2014 Jun 17;9(6):e99320. doi: 10.1371/journal.pone.0099320. eCollection 2014. PubMed PMID: 24937131; PubMed Central PMCID: PMC4061002.

6: Wills KL, Vemuri K, Kalmar A, Lee A, Limebeer CL, Makriyannis A, Parker LA. CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats. Psychopharmacology (Berl). 2014 Nov;231(22):4291-300. doi: 10.1007/s00213-014-3575-5. Epub 2014 Apr 27. Erratum in: Psychopharmacology (Berl). 2014 Nov;231(22):4419-20. PubMed PMID: 24770676; PubMed Central PMCID: PMC4209202.

7: Kangas BD, Delatte MS, Vemuri VK, Thakur GA, Nikas SP, Subramanian KV, Shukla VG, Makriyannis A, Bergman J. Cannabinoid discrimination and antagonism by CB(1) neutral and inverse agonist antagonists. J Pharmacol Exp Ther. 2013 Mar;344(3):561-7. doi: 10.1124/jpet.112.201962. Epub 2013 Jan 3. PubMed PMID: 23287700; PubMed Central PMCID: PMC3583508.

AM4113

10.0mg / USD 305.0