WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525282


Description: V-58 is a novel inhibitor of Mtb replication within macrophages and stimulate cAMP production in Mtb, rapidly and directly activating Mtb AC Rv1625c to produce high levels of cAMP regardless of the bacterial environment or growth medium.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 525282
Name: V-58
Chemical Formula: C17H21ClN4O2S2
Exact Mass: 412.08
Molecular Weight: 412.951
Elemental Analysis: C, 49.45; H, 5.13; Cl, 8.58; N, 13.57; O, 7.75; S, 15.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: V-58, V 58, V58

IUPAC/Chemical Name: 5-Chloro-3-methanesulfonyl-2-[4-(2-methylsulfanyl-pyrimidin-5-ylmethyl)-piperidin-1-yl]pyridine


InChi Code: InChI=1S/C17H21ClN4O2S2/c1-25-17-20-9-13(10-21-17)7-12-3-5-22(6-4-12)16-15(26(2,23)24)8-14(18)11-19-16/h8-12H,3-7H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 412.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017 May 11:1-8. doi: 10.1017/S000711451700085X. [Epub ahead of print] PubMed PMID: 28490394.

2: Johnson RM, Bai G, DeMott CM, Banavali NK, Montague CR, Moon C, Shekhtman A, VanderVen B, McDonough KA. Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling. Mol Microbiol. 2017 May 2. doi: 10.1111/mmi.13701. [Epub ahead of print] PubMed PMID: 28464471.

3: Murray AM, Turner AP, Sproule J, Cardinale M. Practices & attitudes towards recovery in elite Asian & UK adolescent athletes. Phys Ther Sport. 2016 Dec 23;25:25-33. doi: 10.1016/j.ptsp.2016.12.005. [Epub ahead of print] PubMed PMID: 28279844.

4: Sanoff HK, Chang Y, Reimers M, Lund JL. Hospice Utilization and Its Effect on Acute Care Needs at the End of Life in Medicare Beneficiaries With Hepatocellular Carcinoma. J Oncol Pract. 2017 Mar;13(3):e197-e206. doi: 10.1200/JOP.2016.017814. Epub 2016 Dec 28. PubMed PMID: 28029300.

5: Pek PP, Loy EY, Wah W, Ho AF, Zheng H, Fook-Chong SM, Chua TS, Koh TH, Chow KY, Liu N, Ong ME. Reperfusion treatment delays amongst patients with painless ST segment elevation myocardial infarction. CJEM. 2016 Sep 29:1-9. [Epub ahead of print] PubMed PMID: 27681496.

6: Wylie JD, Jones DL, Hartley MK, Kapron AL, Krych AJ, Aoki SK, Maak TG. Distal Femoral Osteotomy for the Valgus Knee: Medial Closing Wedge Versus Lateral Opening Wedge: A Systematic Review. Arthroscopy. 2016 Oct;32(10):2141-2147. doi: 10.1016/j.arthro.2016.04.010. Epub 2016 Jun 3. Review. PubMed PMID: 27265250.


8: Zograf JK, Trebukhova YA, Pavlyuk ON. Description of new species of Phanodermopsis (Enoplida, Phanodermatidae) with key to genera of family Phanodermatidae and pictorial key to Phanodermopsis species. Zootaxa. 2015 Oct 16;4032(3):277-89. doi: 10.11646/zootaxa.4032.3.3. PubMed PMID: 26624362.

9: Laverty AA, Magee L, Monteiro CA, Saxena S, Millett C. Sugar and artificially sweetened beverage consumption and adiposity changes: National longitudinal study. Int J Behav Nutr Phys Act. 2015 Oct 26;12:137. doi: 10.1186/s12966-015-0297-y. PubMed PMID: 26503493; PubMed Central PMCID: PMC4624385.

10: Álvarez-Ortega S, Nguyen TA, Abolafia J, Vu TT, Peña-Santiago R. Three new species of the genus Aporcelaimoides Heyns, 1965 from Vietnam (Nematoda, Dorylaimida, Aporcelaimidae), with an updated taxonomy of the genus. Zookeys. 2015 Aug 6;(516):1-26. doi: 10.3897/zookeys.516.10087. eCollection 2015. PubMed PMID: 26312016; PubMed Central PMCID: PMC4547366.

11: Breen C, Ryan M, Gibney MJ, O'Shea D. Diabetes-related nutrition knowledge and dietary intake among adults with type 2 diabetes. Br J Nutr. 2015 Aug 14;114(3):439-47. doi: 10.1017/S0007114515002068. Epub 2015 Jul 14. PubMed PMID: 26169113.

12: Aviki EM, Rauh-Hain JA, Clark RM, Hall TR, Berkowitz LR, Boruta DM, Growdon WB, Schorge JO, Goodman A. Gynecologic Oncologist as surgical consultant: intraoperative consultations during general gynecologic surgery as an important focus of gynecologic oncology training. Gynecol Oncol. 2015 Apr;137(1):93-7. doi: 10.1016/j.ygyno.2015.01.536. Epub 2015 Jan 21. PubMed PMID: 25617772.

13: Hocking C, Broadbridge VT, Karapetis C, Beeke C, Padbury R, Maddern GJ, Roder DM, Price TJ. Equivalence of outcomes for rural and metropolitan patients with metastatic colorectal cancer in South Australia. Med J Aust. 2014 Oct 20;201(8):462-6. PubMed PMID: 25332033.

14: Budd AC, Brotherton JM, Gertig DM, Chau T, Drennan KT, Saville M. Cervical screening rates for women vaccinated against human papillomavirus. Med J Aust. 2014 Sep 1;201(5):279-82. PubMed PMID: 25163380.

15: Ang KK, Zhang Q, Rosenthal DI, Nguyen-Tan PF, Sherman EJ, Weber RS, Galvin JM, Bonner JA, Harris J, El-Naggar AK, Gillison ML, Jordan RC, Konski AA, Thorstad WL, Trotti A, Beitler JJ, Garden AS, Spanos WJ, Yom SS, Axelrod RS. Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol. 2014 Sep 20;32(27):2940-50. PubMed PMID: 25154822; PubMed Central PMCID: PMC4162493.

16: Shah SS, Todkar JS, Shah PS. Buttressing the staple line: a randomized comparison between staple-line reinforcement versus no reinforcement during sleeve gastrectomy. Obes Surg. 2014 Dec;24(12):2014-20. doi: 10.1007/s11695-014-1374-z. Erratum in: Obes Surg. 2015 Feb;25(2):392. PubMed PMID: 25129485; PubMed Central PMCID: PMC4223405.

17: Doyle O, McGlanaghy E, Palamaro-Munsell E, McAuliffe FM. Home based educational intervention to improve perinatal outcomes for a disadvantaged community: a randomised control trial. Eur J Obstet Gynecol Reprod Biol. 2014 Sep;180:162-7. doi: 10.1016/j.ejogrb.2014.06.006. Epub 2014 Jun 24. PubMed PMID: 25027267.

18: Gold A, Yu N, Buro B, Garden-Robinson J. Discussion map and cooking classes: testing the effectiveness of teaching food safety to immigrants and refugees. J Nutr Educ Behav. 2014 Nov-Dec;46(6):547-53. doi: 10.1016/j.jneb.2013.11.014. Epub 2014 Feb 26. PubMed PMID: 24581813.

19: Fortner HA, Salgado JM, Holmstrup AM, Holmstrup ME. Cardiovascular and Metabolic Demads of the Kettlebell Swing using Tabata Interval versus a Traditional Resistance Protocol. Int J Exerc Sci. 2014 Jul 1;7(3):179-185. eCollection 2014. PubMed PMID: 27182402; PubMed Central PMCID: PMC4831858.

20: Curtis JA, Hollinger MK, Jain HB. Propofol-based versus dexmedetomidine-based sedation in cardiac surgery patients. J Cardiothorac Vasc Anesth. 2013 Dec;27(6):1289-94. doi: 10.1053/j.jvca.2013.03.022. Epub 2013 Sep 5. PubMed PMID: 24011878.