WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407484
CAS#: 1422269-30-4
Description: ML18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). ML-18 inhibits lung cancer growth. ML-18 inhibited the proliferation of lung cancer cells. ML-18 is a nonpeptide BRS-3 antagonist that should serve as a template to improve potency and selectivity.
MedKoo Cat#: 407484
Name: ML-18
CAS#: 1422269-30-4
Chemical Formula: C32H35N5O5
Exact Mass: 569.2638
Molecular Weight: 569.662
Elemental Analysis: C, 67.47; H, 6.19; N, 12.29; O, 14.04
Synonym: ML-18; ML 18; ML18.
IUPAC/Chemical Name: (S)-3-(1H-indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide
InChi Key: JOKVJNCYOSFDGC-LJAQVGFWSA-N
InChi Code: InChI=1S/C32H35N5O5/c1-42-26-15-9-23(10-16-26)32(17-5-2-6-18-32)21-34-30(38)29(19-22-20-33-28-8-4-3-7-27(22)28)36-31(39)35-24-11-13-25(14-12-24)37(40)41/h3-4,7-16,20,29,33H,2,5-6,17-19,21H2,1H3,(H,34,38)(H2,35,36,39)/t29-/m0/s1
SMILES Code: O=C(NC1=CC=C([N+]([O-])=O)C=C1)N[C@H](C(NCC2(C3=CC=C(OC)C=C3)CCCCC2)=O)CC4=CNC5=C4C=CC=C5
1: Moody TW, Mantey SA, Moreno P, Nakamura T, Lacivita E, Leopoldo M, Jensen RT.
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung
cancer growth. Peptides. 2015 Feb;64:55-61. doi: 10.1016/j.peptides.2014.12.005.
Epub 2014 Dec 30. PubMed PMID: 25554218; PubMed Central PMCID: PMC4397132.