NIR-II fluorophore-H1

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525232


Description: NIR-II fluorophore-H1 is a novel precursor of bright-emission NIR-II fluorophores for in vivo tumor imaging and image-guided surgery.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-11-25. Prices are subject to change without notice.

NIR-II fluorophore-H1 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 525232
Name: NIR-II fluorophore-H1
Chemical Formula: C72H90N6O8S4Si4
Exact Mass: 1406.478
Molecular Weight: 1408.126
Elemental Analysis: C, 61.41; H, 6.44; N, 5.97; O, 9.09; S, 9.11; Si, 7.98

Synonym: NIR-II fluorophore-H1

IUPAC/Chemical Name: 3,6-Bis[5-{7-Amino-9,9-bis-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-9H-fluoren-2-yl}-thiophene-2-yl]benzo[1,2-c;4,5-c']bis[1,2,5]thiadiazole


InChi Code: InChI=1S/C72H90N6O8S4Si4/c1-91(2,3)37-33-83-66(79)25-29-71(30-26-67(80)84-34-38-92(4,5)6)55-41-47(13-17-51(55)53-19-15-49(73)43-57(53)71)63-21-23-65(87-63)78-62-46-60-59(45-61(62)75-89-78)76-90(77-60)70-24-22-64(88-70)48-14-18-52-54-20-16-50(74)44-58(54)72(56(52)42-48,31-27-68(81)85-35-39-93(7,8)9)32-28-69(82)86-36-40-94(10,11)12/h13-24,41-46H,25-40,73-74H2,1-12H3

SMILES Code: O=C(CCC1(CCC(OCC[Si](C)(C)C)=O)C2=C(C3=C1C=C(N)C=C3)C=CC(C4=CC=C(S5=NC6=CC7=NSN(C8=CC=C(C9=CC(C(CCC(OCC[Si](C)(C)C)=O)(CCC(OCC[Si](C)(C)C)=O)C%10=C%11C=CC(N)=C%10)=C%11C=C9)S8)C7=CC6=N5)S4)=C2)OCC[Si](C)(C)C

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Wu Q, Zhou M, Shi J, Li Q, Yang M, Zhang Z. Synthesis of Water-Soluble Ag(2)S Quantum Dots with Fluorescence in the Second Near-Infrared Window for Turn-on Detection of Zn(II) and Cd(II). Anal Chem. 2017 May 16. doi: 10.1021/acs.analchem.7b00777. [Epub ahead of print] PubMed PMID: 28509528.

2: Sun Y, Ding M, Zeng X, Xiao Y, Wu H, Zhou H, Ding B, Qu C, Hou W, Er-Bu A, Zhang Y, Cheng Z, Hong X. Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery. Chem Sci. 2017 May 1;8(5):3489-3493. doi: 10.1039/c7sc00251c. Epub 2017 Feb 21. PubMed PMID: 28507722; PubMed Central PMCID: PMC5418643.

3: Argueta-Figueroa L, Martínez-Alvarez O, Santos-Cruz J, Garcia-Contreras R, Acosta-Torres LS, de la Fuente-Hernández J, Arenas-Arrocena MC. Nanomaterials made of non-toxic metallic sulfides: A systematic review of their potential biomedical applications. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1305-1315. doi: 10.1016/j.msec.2017.02.120. Epub 2017 Feb 27. Review. PubMed PMID: 28482499.

4: Tao Z, Dang X, Huang X, Muzumdar MD, Xu ES, Bardhan NM, Song H, Qi R, Yu Y, Li T, Wei W, Wyckoff J, Birrer MJ, Belcher AM, Ghoroghchian PP. Early tumor detection afforded by in vivo imaging of near-infrared II fluorescence. Biomaterials. 2017 Jul;134:202-215. doi: 10.1016/j.biomaterials.2017.04.046. Epub 2017 Apr 25. PubMed PMID: 28482280.

5: Yu X, Li A, Zhao C, Yang K, Chen X, Li W. Ultrasmall Semimetal Nanoparticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic Thermoradiotherapy. ACS Nano. 2017 Apr 25;11(4):3990-4001. doi: 10.1021/acsnano.7b00476. Epub 2017 Apr 12. PubMed PMID: 28395135.

6: Li S, Xu L, Sun M, Wu X, Liu L, Kuang H, Xu C. Hybrid Nanoparticle Pyramids for Intracellular Dual MicroRNAs Biosensing and Bioimaging. Adv Mater. 2017 May;29(19). doi: 10.1002/adma.201606086. Epub 2017 Feb 21. PubMed PMID: 28221715.

7: Jeong S, Song J, Lee W, Ryu YM, Jung Y, Kim SY, Kim K, Hong SC, Myung SJ, Kim S. Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window. Nano Lett. 2017 Mar 8;17(3):1378-1386. doi: 10.1021/acs.nanolett.6b04261. Epub 2017 Feb 1. PubMed PMID: 28125238.

8: Yang T, Tang Y, Liu L, Lv X, Wang Q, Ke H, Deng Y, Yang H, Yang X, Liu G, Zhao Y, Chen H. Size-Dependent Ag(2)S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy. ACS Nano. 2017 Feb 28;11(2):1848-1857. doi: 10.1021/acsnano.6b07866. Epub 2017 Jan 31. PubMed PMID: 28117993.

9: Yang Q, Ma Z, Wang H, Zhou B, Zhu S, Zhong Y, Wang J, Wan H, Antaris A, Ma R, Zhang X, Yang J, Zhang X, Sun H, Liu W, Liang Y, Dai H. Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window. Adv Mater. 2017 Mar;29(12). doi: 10.1002/adma.201605497. Epub 2017 Jan 24. PubMed PMID: 28117499.

10: Zhu S, Yang Q, Antaris AL, Yue J, Ma Z, Wang H, Huang W, Wan H, Wang J, Diao S, Zhang B, Li X, Zhong Y, Yu K, Hong G, Luo J, Liang Y, Dai H. Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):962-967. doi: 10.1073/pnas.1617990114. Epub 2017 Jan 17. PubMed PMID: 28096386; PubMed Central PMCID: PMC5293099.

11: Kim D, Lee N, Park YI, Hyeon T. Recent Advances in Inorganic Nanoparticle-Based NIR Luminescence Imaging: Semiconductor Nanoparticles and Lanthanide Nanoparticles. Bioconjug Chem. 2017 Jan 18;28(1):115-123. doi: 10.1021/acs.bioconjchem.6b00654. Epub 2016 Dec 16. PubMed PMID: 27982578.

12: Mishra SK, Kannan S. Microwave Synthesis of Chitosan Capped Silver-Dysprosium Bimetallic Nanoparticles: A Potential Nanotheranosis Device. Langmuir. 2016 Dec 27;32(51):13687-13696. doi: 10.1021/acs.langmuir.6b03438. Epub 2016 Dec 16. PubMed PMID: 27981845.

13: Shao W, Chen G, Kuzmin A, Kutscher HL, Pliss A, Ohulchanskyy TY, Prasad PN. Tunable Narrow Band Emissions from Dye-Sensitized Core/Shell/Shell Nanocrystals in the Second Near-Infrared Biological Window. J Am Chem Soc. 2016 Dec 21;138(50):16192-16195. doi: 10.1021/jacs.6b08973. Epub 2016 Dec 9. PubMed PMID: 27935695.

14: Zhang X, Li Y, Liao C, Chen Z, Qiu J. Controllable Synthesis of Mn(6+) Doped Nanoparticles by a Facile Anion Exchange Method. Nanotechnology. 2017 Jan 13;28(2):025604. Epub 2016 Dec 7. PubMed PMID: 27924787.

15: Fang L, Wang Y, Liu M, Gong M, Xu A, Deng Z. Dry Sintering Meets Wet Silver-Ion "Soldering": Charge-Transfer Plasmon Engineering of Solution-Assembled Gold Nanodimers From Visible to Near-Infrared I and II Regions. Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14296-14300. doi: 10.1002/anie.201608271. Epub 2016 Oct 12. PubMed PMID: 27730722.

16: Li A, Li X, Yu X, Li W, Zhao R, An X, Cui D, Chen X, Li W. Synergistic thermoradiotherapy based on PEGylated Cu(3)BiS(3) ternary semiconductor nanorods with strong absorption in the second near-infrared window. Biomaterials. 2017 Jan;112:164-175. doi: 10.1016/j.biomaterials.2016.10.024. Epub 2016 Oct 12. PubMed PMID: 27768971.

17: Levy ES, Tajon CA, Bischof TS, Iafrati J, Fernandez-Bravo A, Garfield DJ, Chamanzar M, Maharbiz MM, Sohal VS, Schuck PJ, Cohen BE, Chan EM. Energy-Looping Nanoparticles: Harnessing Excited-State Absorption for Deep-Tissue Imaging. ACS Nano. 2016 Sep 27;10(9):8423-33. doi: 10.1021/acsnano.6b03288. Epub 2016 Sep 7. PubMed PMID: 27603228.

18: Li X, Zhang Q, Ahmad Z, Huang J, Ren Z, Weng W, Han G, Mao C. Near-infrared luminescent CaTiO(3):Nd(3+) nanofibers with tunable and trackable drug release kinetics. J Mater Chem B Mater Biol Med. 2015 Oct 7;3(37):7449-7456. Epub 2015 Aug 28. PubMed PMID: 27398215; PubMed Central PMCID: PMC4934121.

19: Theodorou IG, Jawad ZA, Qin H, Aboagye EO, Porter AE, Ryan MP, Xie F. Significant metal enhanced fluorescence of Ag2S quantum dots in the second near-infrared window. Nanoscale. 2016 Jul 14;8(26):12869-73. doi: 10.1039/c6nr03220f. Epub 2016 Jun 17. PubMed PMID: 27314986.

20: Hong G, Dai H. In Vivo Fluorescence Imaging in the Second Near-Infrared Window Using Carbon Nanotubes. Methods Mol Biol. 2016;1444:167-81. doi: 10.1007/978-1-4939-3721-9_15. PubMed PMID: 27283426.