Altrenogest
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MedKoo CAT#: 329657

CAS#: 850-52-2

Description: Altrenogest, also known as allyltrenbolone or allyltrienolone, is a steroidal progestin of the 19-nortestosterone and allyltestosterone groups related to allylestrenol, norgestrienone, and trenbolone that is widely used in veterinary medicine to suppress or synchronize estrus in horses and pigs. It is available for veterinary use in both Europe (as Regumate) and the United States (as Matrix), and has been marketed as Regumate since the early 1980s.


Chemical Structure

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Altrenogest
CAS# 850-52-2

Theoretical Analysis

MedKoo Cat#: 329657
Name: Altrenogest
CAS#: 850-52-2
Chemical Formula: C21H26O2
Exact Mass: 310.1933
Molecular Weight: 310.437
Elemental Analysis: C, 81.25; H, 8.44; O, 10.31

Price and Availability

Size Price Availability Quantity
100.0mg USD 150.0 2 Weeks
200.0mg USD 250.0 2 Weeks
500.0mg USD 450.0 2 Weeks
1.0g USD 650.0 2 Weeks
2.0g USD 950.0 2 Weeks
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Synonym: Altrenogest; A 35957; A-35957; Allyl trenbolone; DRC 6246; R 2267; REGU-MATE; Regumate; RU 2267; RU-2267.

IUPAC/Chemical Name: (8S,13S,14S,17R)-17-allyl-17-hydroxy-13-methyl-1,2,6,7,8,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one

InChi Key: VWAUPFMBXBWEQY-ANULTFPQSA-N

InChi Code: InChI=1S/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/m1/s1

SMILES Code: C[C@@]12[C@@](CC=C)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3C=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 310.437 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Micheletti T, Brown JL, Walker SL, Cubas ZS, Furtado PV, Putman SB, de Moraes W, de Oliveira MJ, de Oliveira CA, Moreira N. The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus). Theriogenology. 2015 Sep 1;84(4):575-82. doi: 10.1016/j.theriogenology.2015.04.015. Epub 2015 Apr 28. PubMed PMID: 26001599.

2: van Leeuwen JJ, Martens MR, Jourquin J, Driancourt MA, Wagner A, Kemp B, Soede NM. Follicle size and reproductive hormone profiles during a post-weaning altrenogest treatment in primiparous sows. Reprod Fertil Dev. 2015 Jan;27(2):304-12. doi: 10.1071/RD13149. PubMed PMID: 24192203.

3: McConaghy FF, Green LA, Colgan S, Morris LH. Studies of the pharmacokinetic profile, in vivo efficacy and safety of injectable altrenogest for the suppression of oestrus in mares. Aust Vet J. 2016 Jul;94(7):248-55. doi: 10.1111/avj.12459. PubMed PMID: 27349885.

4: Vallejo Aristizabal VH, Mogollón Garcia HD, Dell'aqua Junior JA. 98 INFLUENCE OF INJECTION ALTRENOGEST IN UTERINE TONE AND EMBRYONIC VESICLE GROWTH IN RECIPIENT MARES. Reprod Fertil Dev. 2016 Jan;29(1):157. doi: 10.1071/RDv29n1Ab98. PubMed PMID: 28278895.

5: van Leeuwen JJ, Martens MR, Jourquin J, Driancourt MA, Kemp B, Soede NM. Effects of altrenogest treatments before and after weaning on follicular development, farrowing rate, and litter size in sows. J Anim Sci. 2011 Aug;89(8):2397-406. doi: 10.2527/jas.2010-3752. Epub 2011 Mar 18. PubMed PMID: 21421833.

6: Willmann C, Budik S, Walter I, Aurich C. Influences of treatment of early pregnant mares with the progestin altrenogest on embryonic development and gene expression in the endometrium and conceptus. Theriogenology. 2011 Jul 1;76(1):61-73. doi: 10.1016/j.theriogenology.2011.01.018. Epub 2011 Mar 11. PubMed PMID: 21396689.

7: Gaggini TS, Perin J, Arend LS, Bernardi ML, Wentz I, Bortolozzo FP. Altrenogest treatment associated with a farrowing induction protocol to avoid early parturition in sows. Reprod Domest Anim. 2013 Jun;48(3):390-5. doi: 10.1111/rda.12085. Epub 2012 Sep 21. PubMed PMID: 22994857.

8: Willmann C, Schuler G, Hoffmann B, Parvizi N, Aurich C. Effects of age and altrenogest treatment on conceptus development and secretion of LH, progesterone and eCG in early-pregnant mares. Theriogenology. 2011 Feb;75(3):421-8. doi: 10.1016/j.theriogenology.2010.05.009. Epub 2010 Dec 7. PubMed PMID: 21144568.

9: van Leeuwen JJ, Williams SI, Martens MR, Jourquin J, Driancourt MA, Kemp B, Soede NM. The effect of different postweaning altrenogest treatments of primiparous sows on follicular development, pregnancy rates, and litter sizes. J Anim Sci. 2011 Feb;89(2):397-403. doi: 10.2527/jas.2010-3246. Epub 2010 Oct 15. PubMed PMID: 20952527.

10: Crosier AE, Comizzoli P, Koester DC, Wildt DE. Circumventing the natural, frequent oestrogen waves of the female cheetah (Acinonyx jubatus) using oral progestin (Altrenogest). Reprod Fertil Dev. 2016 Aug 3. doi: 10.1071/RD16007. [Epub ahead of print] PubMed PMID: 27483379.

11: Palm FM, Schenk I, Neuhauser S, Schubert D, Machnik M, Schänzer W, Aurich C. Concentrations of altrenogest in plasma of mares and foals and in allantoic and amniotic fluid at parturition. Theriogenology. 2010 Jul 15;74(2):229-35. doi: 10.1016/j.theriogenology.2010.02.006. Epub 2010 May 10. PubMed PMID: 20452000.

12: van Leeuwen JJ, Williams SI, Kemp B, Soede NM. Post-weaning Altrenogest treatment in primiparous sows; the effect of duration and dosage on follicular development and consequences for early pregnancy. Anim Reprod Sci. 2010 Jun;119(3-4):258-64. doi: 10.1016/j.anireprosci.2010.02.008. Epub 2010 Feb 18. PubMed PMID: 20223607.

13: Foisnet A, Farmer C, David C, Quesnel H. Altrenogest treatment during late pregnancy did not reduce colostrum yield in primiparous sows. J Anim Sci. 2010 May;88(5):1684-93. doi: 10.2527/jas.2009-2751. Epub 2010 Jan 29. PubMed PMID: 20118420.

14: Ziecik AJ, Klos J, Przygrodzka E, Milewski R, Jana B. Aberrant effects of altrenogest and exposure to exogenous gonadotropins on follicular cysts appearance in gilts. Theriogenology. 2017 Feb;89:250-254. doi: 10.1016/j.theriogenology.2016.10.028. Epub 2016 Nov 9. PubMed PMID: 28043359.

15: van Leeuwen JJ, Martens MR, Jourquin J, Driancourt MA, Kemp B, Soede NM. Variation in LH pulsatility during 24h after a postweaning altrenogest treatment in relation to follicle development in primiparous sows. Anim Reprod Sci. 2011 Jun;126(1-2):101-7. doi: 10.1016/j.anireprosci.2011.04.015. Epub 2011 Apr 29. PubMed PMID: 21571457.

16: Neuhauser S, Palm F, Ambuehl F, Möstl E, Schwendenwein I, Aurich C. Effect of altrenogest-treatment of mares in late gestation on adrenocortical function, blood count and plasma electrolytes in their foals. Equine Vet J. 2009 Jul;41(6):572-7. PubMed PMID: 19803053.

17: van Leeuwen JJ, Verhoeven M, van der Heden-van Noort I, Kranenbarg S, Kemp B, Soede NM. Split-weaning before altrenogest synchronization of multiparous sows alters follicular development and reduces embryo survival. Reprod Domest Anim. 2012 Aug;47(4):530-6. doi: 10.1111/j.1439-0531.2011.01913.x. Epub 2011 Oct 12. PubMed PMID: 21988454.

18: Zhang D, Park JA, Kim SK, Cho SH, Cho SM, Yi H, Shim JH, Kim JS, Abd El-Aty AM, Shin HC. Determination of residual levels of naloxone, yohimbine, thiophanate, and altrenogest in porcine muscle using QuEChERS with liquid chromatography and triple quadrupole mass spectrometry. J Sep Sci. 2016 Mar;39(5):835-41. doi: 10.1002/jssc.201501206. Epub 2016 Jan 28. PubMed PMID: 26697949.

19: Werlang RF, Argenti LE, Fries HC, Bernardi ML, Wentz I, Bortolozzo FP. Effects of breeding at the second oestrus or after post-weaning hormonal treatment with altrenogest on subsequent reproductive performance of primiparous sows. Reprod Domest Anim. 2011 Oct;46(5):818-23. doi: 10.1111/j.1439-0531.2010.01747.x. Epub 2011 Feb 16. PubMed PMID: 21323753.

20: Neuhauser S, Palm F, Ambuehl F, Aurich C. Effects of altrenogest treatment of mares in late pregnancy on parturition and on neonatal viability of their foals. Exp Clin Endocrinol Diabetes. 2008 Jul;116(7):423-8. doi: 10.1055/s-2008-1065367. Epub 2008 May 16. PubMed PMID: 18484066.