SB399885 HCl
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MedKoo CAT#: 532666

CAS#: 402713-81-9 (HCl)

Description: SB 399885 hydrochloride is a potent, brain penetrant, and orally active SR-6 antagonist. It displays > 200-fold selectivity for SR-6 over other serotonin receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human SR-6 receptors, respectively).

Chemical Structure

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SB399885 HCl
CAS# 402713-81-9 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 532666
Name: SB399885 HCl
CAS#: 402713-81-9 (HCl)
Chemical Formula: C18H22Cl3N3O4S
Exact Mass: 0.00
Molecular Weight: 482.800
Elemental Analysis: C, 44.78; H, 4.59; Cl, 22.03; N, 8.70; O, 13.26; S, 6.64

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10mg USD 550 2 Weeks
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Related CAS #: 402713-80-8(free base)   402713-81-9 (HCl)    

Synonym: SB399885 HCl; SB399885; SB399885 Hydrochloride; SB 399885; SB-399885.

IUPAC/Chemical Name: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamidehydrochloride

InChi Key: RNKCEBCFUSXSQE-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21Cl2N3O4S.ClH/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2;/h3-4,9-11,21-22H,5-8H2,1-2H3;1H

SMILES Code: O=S(C1=CC=C(OC)C(N2CCNCC2)=C1)(NC3=CC(Cl)=CC(Cl)=C3OC)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 482.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Abraham R, Nirogi R, Shinde A, Benade VS. Therapeutic Potential of 5-HT6 Antagonist SB399885 in Traumatic Stress Disorder. Drug Res (Stuttg). 2015 Aug;65(8):442-5. doi: 10.1055/s-0034-1390418. Epub 2014 Oct 13. PubMed PMID: 25310249.