BAR-502
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530640

CAS#: 1612191-86-2

Description: BAR502 is a dual FXR and GPBAR1 agonist. BAR-502 promotes browning of white adipose tissue and reverses liver steatosis and fibrosis. BAR502 protects against liver damage caused by HFD by promoting the browning of adipose tissue.


Price and Availability

Size
Price

100mg
USD 1250
1g
USD 3850
Size
Price

200mg
USD 1850
2g
USD 5950
Size
Price

500mg
USD 2850
5g
USD 9850

BAR-502, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530640
Name: BAR-502
CAS#: 1612191-86-2
Chemical Formula: C25H44O3
Exact Mass: 392.329
Molecular Weight: 392.624
Elemental Analysis: C, 76.48; H, 11.30; O, 12.22


Synonym: BAR-502; BAR 502; BAR502.

IUPAC/Chemical Name: (3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-4-hydroxybutan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol

InChi Key: HYCMOIGNYNCMRH-APIYUPOTSA-N

InChi Code: InChI=1S/C25H44O3/c1-5-17-21-14-16(27)8-11-25(21,4)20-9-12-24(3)18(15(2)10-13-26)6-7-19(24)22(20)23(17)28/h15-23,26-28H,5-14H2,1-4H3/t15-,16-,17-,18-,19+,20+,21+,22+,23-,24-,25-/m1/s1

SMILES Code: O[C@@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@@H](CCO)C)CC[C@@]4([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]2([H])C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Non-alcoholic steatohepatitis (NASH) is a highly prevalent chronic liver disease.


References

1: Carino A, Cipriani S, Marchianò S, Biagioli M, Santorelli C, Donini A,
Zampella A, Monti MC, Fiorucci S. BAR502, a dual FXR and GPBAR1 agonist, promotes
browning of white adipose tissue and reverses liver steatosis and fibrosis. Sci
Rep. 2017 Feb 16;7:42801. doi: 10.1038/srep42801. PubMed PMID: 28202906; PubMed
Central PMCID: PMC5311892.

2: Cipriani S, Renga B, D'Amore C, Simonetti M, De Tursi AA, Carino A, Monti MC,
Sepe V, Zampella A, Fiorucci S. Impaired Itching Perception in Murine Models of
Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling. PLoS One. 2015 Jul
15;10(7):e0129866. doi: 10.1371/journal.pone.0129866. eCollection 2015. PubMed
PMID: 26177448; PubMed Central PMCID: PMC4503431.