MDK6664
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407478

CAS#: 1017606-66-4

Description: MDK6664, also known as LPA2-IN-1 or LPA2 antagonist 1, is a potent LPA2 antagonist with IC50 17 nM in vitro for inhibition of LPA(2) mediated Erk activation and proliferation of HCT-116 cells. Lysophosphatidic acid (LPA) acts via binding to specific G protein-coupled receptors and has been implicated in the biology of breast cancer.

Chemical Structure

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MDK6664
CAS# 1017606-66-4
Instruction

Theoretical Analysis

MedKoo Cat#: 407478
Name: MDK6664
CAS#: 1017606-66-4
Chemical Formula: C20H23Cl2N5O2S2
Exact Mass: 499.07
Molecular Weight: 500.457
Elemental Analysis: C, 48.00; H, 4.63; Cl, 14.17; N, 13.99; O, 6.39; S, 12.81

Price and Availability

Size Price Availability Quantity
5mg USD 550 2 weeks
10mg USD 950 2 weeks
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Synonym: MDK6664; MDK-6664; MDK 6664; LPA2 antagonist 1; LPA2-IN-1.

IUPAC/Chemical Name: (S)-{2-[4-(3,4-Dichloro-benzenesulfonyl)-piperazin-1-yl]-1-methyl-ethyl}-(7-methyl-thieno[3,2-d]pyrimidin-4-yl)-amine

InChi Key: BPRNMVDTWIHULJ-AWEZNQCLSA-N

InChi Code: InChI=1S/C20H23Cl2N5O2S2/c1-13-11-30-19-18(13)23-12-24-20(19)25-14(2)10-26-5-7-27(8-6-26)31(28,29)15-3-4-16(21)17(22)9-15/h3-4,9,11-12,14H,5-8,10H2,1-2H3,(H,23,24,25)/t14-/m0/s1

SMILES Code: CC1=CSC2=C(N[C@@H](C)CN3CCN(S(=O)(C4=CC=C(Cl)C(Cl)=C4)=O)CC3)N=CN=C21

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 500.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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