S26131 | CAS#296280-56-3

S26131
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532617

CAS#: 296280-56-3

Description: S26131 is a bioactive chemical.

Chemical Structure

S26131

CAS# 296280-56-3

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 532617
Name: S26131
CAS#: 296280-56-3
Chemical Formula: C31H34N2O4
Exact Mass: 498.25
Molecular Weight: 498.620
Elemental Analysis: C, 74.67; H, 6.87; N, 5.62; O, 12.83

Price and Availability

Size	Price	Availability
5mg	USD 90	Ready to ship
10mg	USD 150	Ready to ship
25mg	USD 250	Ready to ship
50mg	USD 450	Ready to ship
100mg	USD 750	Ready to ship
200mg	USD 1350	Ready to ship
500mg	USD 2850	Ready to ship
1g	USD 3850	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: S26131; S 26131; S-26131.

IUPAC/Chemical Name: N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide

InChi Key: NSXBZYDTTKLTOH-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H34N2O4/c1-22(34)32-16-14-26-8-3-6-24-10-12-28(20-30(24)26)36-18-5-19-37-29-13-11-25-7-4-9-27(31(25)21-29)15-17-33-23(2)35/h3-4,6-13,20-21H,5,14-19H2,1-2H3,(H,32,34)(H,33,35)

SMILES Code: CC(NCCC1=C2C=C(OCCCOC3=CC=C4C=CC=C(CCNC(C)=O)C4=C3)C=CC2=CC=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#S9S07C15

QC Data:

View QC data: current batch, Lot#S9S07C15

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	S26131 is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively.
In vitro activity:	S26131 was used to block the MT1 receptor. By inhibiting the MT1 receptor, S26131 was employed to investigate the role of the MT1 receptor in the proliferation of porcine skin-derived stem cell-derived primordial germ cell-like cells to investigate how melatonin promotes the proliferation of PGCLCs and its potential involvement in the mitogen-activated protein kinase signaling pathway. Reference: J Pineal Res. 2022 Nov;73(4):e12833. https://pubmed.ncbi.nlm.nih.gov/36106819/
In vivo activity:	S26131 was used as an MT1 receptor antagonist to study the effects of melatonin on bladder sensory neurons. Melatonin had inhibitory effects on the mechanosensitivity of certain bladder afferents, specifically the low threshold stretch-sensitive muscular-mucosal bladder afferents, by acting through the MT2 receptors. This suggests that S26131, as an MT1 receptor antagonist, did not block the inhibitory effects of melatonin. Reference: Sci Rep. 2022 Oct 21;12(1):17686. https://pubmed.ncbi.nlm.nih.gov/36271291/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	5.0	10.03

Preparing Stock Solutions

The following data is based on the product molecular weight 498.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Liu WX, Tan SJ, Wang YF, Zhang FL, Feng YQ, Ge W, Dyce PW, Reiter RJ, Shen W, Cheng SF. Melatonin promotes the proliferation of primordial germ cell-like cells derived from porcine skin-derived stem cells: A mechanistic analysis. J Pineal Res. 2022 Nov;73(4):e12833. doi: 10.1111/jpi.12833. Epub 2022 Sep 22. PMID: 36106819. 2. Huang CT, Chen SH, Chang CF, Lin SC, Lue JH, Tsai YJ. Melatonin reduces neuropathic pain behavior and glial activation through MT2 melatonin receptor modulation in a rat model of lysophosphatidylcholine-induced demyelination neuropathy. Neurochem Int. 2020 Nov;140:104827. doi: 10.1016/j.neuint.2020.104827. Epub 2020 Aug 24. PMID: 32853748. 3. Ramsay S, Zagorodnyuk V. Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors. Sci Rep. 2022 Oct 21;12(1):17686. doi: 10.1038/s41598-022-22705-z. PMID: 36271291; PMCID: PMC9586995.
In vitro protocol:	1. Liu WX, Tan SJ, Wang YF, Zhang FL, Feng YQ, Ge W, Dyce PW, Reiter RJ, Shen W, Cheng SF. Melatonin promotes the proliferation of primordial germ cell-like cells derived from porcine skin-derived stem cells: A mechanistic analysis. J Pineal Res. 2022 Nov;73(4):e12833. doi: 10.1111/jpi.12833. Epub 2022 Sep 22. PMID: 36106819. 2. Huang CT, Chen SH, Chang CF, Lin SC, Lue JH, Tsai YJ. Melatonin reduces neuropathic pain behavior and glial activation through MT2 melatonin receptor modulation in a rat model of lysophosphatidylcholine-induced demyelination neuropathy. Neurochem Int. 2020 Nov;140:104827. doi: 10.1016/j.neuint.2020.104827. Epub 2020 Aug 24. PMID: 32853748.
In vivo protocol:	1. Ramsay S, Zagorodnyuk V. Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors. Sci Rep. 2022 Oct 21;12(1):17686. doi: 10.1038/s41598-022-22705-z. PMID: 36271291; PMCID: PMC9586995.

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Huang CT, Chen SH, Chang CF, Lin SC, Lue JH, Tsai YJ. Melatonin Reduces Neuropathic Pain Behavior and Glial Activation through MT2 Melatonin Receptor Modulation in a Rat Model of Lysophosphatidylcholine-Induced Demyelination Neuropathy [published online ahead of print, 2020 Aug 24]. Neurochem Int. 2020;104827. doi:10.1016/j.neuint.2020.104827

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