S 14506 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532609

CAS#: 135722-25-7 (S14506), 286369-38-8(S 14506HCl).

Description: S 14506 HCl is a highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). It potentially binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity.

Price and Availability




S 14506 HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 532609
Name: S 14506 HCl
CAS#: 135722-25-7 (S14506), 286369-38-8(S 14506HCl).
Chemical Formula: C24H27ClFN3O2
Exact Mass:
Molecular Weight: 443.95
Elemental Analysis: C, 64.93; H, 6.13; Cl, 7.99; F, 4.28; N, 9.47; O, 7.21

Related CAS #: 135722-25-7 (S14506)   286369-38-8(S 14506HCl).  

Synonym: S 14506 HCl; S14506HCl; S14506 HCl; S-14506.

IUPAC/Chemical Name: 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride


InChi Code: InChI=1S/C24H26FN3O2.ClH/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19;/h2-10,17H,11-16H2,1H3,(H,26,29);1H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Milligan G, Kellett E, Dacquet C, Dubreuil V, Jacoby E, Millan MJ, Lavielle G, Spedding M. S 14506: novel receptor coupling at 5-HT(1A) receptors. Neuropharmacology. 2001 Mar;40(3):334-44. PubMed PMID: 11166326.

2: Lima L, Laporte AM, Gaymard C, Spedding M, Mocaër E, Hamon M. Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors. J Neural Transm (Vienna). 1997;104(10):1059-75. PubMed PMID: 9503258.

3: Schreiber R, Brocco M, Gobert A, Veiga S, Millan MJ. The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. Eur J Pharmacol. 1994 Dec 27;271(2-3):537-41. PubMed PMID: 7705455.

4: Protais P, Chagraoui A, Arbaoui J, Mocaër E. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271(1):167-77. PubMed PMID: 7698199.

5: Goudie AJ, Leathley MJ. Assessment of the dependence potential of the potent high-efficacy 5-HT1A agonist S-14506 in rats. J Psychopharmacol. 1994 Jan;8(4):213-21. doi: 10.1177/026988119400800404. PubMed PMID: 22298627.