S14506 HCl

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MedKoo CAT#: 532609

CAS#: 286369-38-8 (HCl)

Description: S 14506 is a highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). It potentially binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity.

Chemical Structure

S14506 HCl
CAS# 286369-38-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 532609
Name: S14506 HCl
CAS#: 286369-38-8 (HCl)
Chemical Formula: C24H27ClFN3O2
Exact Mass: 0.00
Molecular Weight: 443.950
Elemental Analysis: C, 64.93; H, 6.13; Cl, 7.99; F, 4.28; N, 9.47; O, 7.21

Price and Availability

Size Price Availability Quantity
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2950 2 Weeks
1g USD 4250 2 Weeks
2g USD 6950 2 Weeks
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Related CAS #: 135722-25-7 (free base)   286369-38-8 (HCl)    

Synonym: S 14506 HCl; S14506HCl; S14506 HCl; S-14506.

IUPAC/Chemical Name: 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride


InChi Code: InChI=1S/C24H26FN3O2.ClH/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19;/h2-10,17H,11-16H2,1H3,(H,26,29);1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 443.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Milligan G, Kellett E, Dacquet C, Dubreuil V, Jacoby E, Millan MJ, Lavielle G, Spedding M. S 14506: novel receptor coupling at 5-HT(1A) receptors. Neuropharmacology. 2001 Mar;40(3):334-44. PubMed PMID: 11166326.

2: Lima L, Laporte AM, Gaymard C, Spedding M, Mocaër E, Hamon M. Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors. J Neural Transm (Vienna). 1997;104(10):1059-75. PubMed PMID: 9503258.

3: Schreiber R, Brocco M, Gobert A, Veiga S, Millan MJ. The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. Eur J Pharmacol. 1994 Dec 27;271(2-3):537-41. PubMed PMID: 7705455.

4: Protais P, Chagraoui A, Arbaoui J, Mocaër E. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271(1):167-77. PubMed PMID: 7698199.

5: Goudie AJ, Leathley MJ. Assessment of the dependence potential of the potent high-efficacy 5-HT1A agonist S-14506 in rats. J Psychopharmacol. 1994 Jan;8(4):213-21. doi: 10.1177/026988119400800404. PubMed PMID: 22298627.