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AS-2444697 HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530638

CAS#: 1287665-60-4 (HCl)

Description: AS-2444697 is a RAK-4 inhibitor. Six weeks' repeated administration of AS2444697 (0.3-3 mg/kg, twice daily) dose-dependently and significantly reduced urinary protein excretion and prevented the development of glomerulosclerosis and interstitial fibrosis without affecting the blood pressure. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. AS2444697 suppresses the progression of chronic renal failure via anti-inflammatory action and may therefore be potentially useful in treating CKD patients.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 1050 2 Weeks
200mg USD 1750 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 4950 2 Weeks
5g USD 8950 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2020-10-28. Prices are subject to change without notice.

AS-2444697 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530638
Name: AS-2444697 HCl
CAS#: 1287665-60-4 (HCl)
Chemical Formula: C19H21ClN6O4
Exact Mass:
Molecular Weight: 432.865
Elemental Analysis: C, 52.72; H, 4.89; Cl, 8.19; N, 19.42; O, 14.78


Related CAS #: 1287665-60-4 (HCl)   1287665-58-0 (free base)    

Synonym: AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride.

IUPAC/Chemical Name: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride

InChi Key: FGNHLIIFEDYNFZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20N6O4.ClH/c1-11-8-12(2-5-21-11)19-23-15(10-29-19)18(27)22-14-9-25(24-16(14)17(20)26)13-3-6-28-7-4-13;/h2,5,8-10,13H,3-4,6-7H2,1H3,(H2,20,26)(H,22,27);1H

SMILES Code: O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=CN(C4CCOCC4)N=C3C(N)=O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Renal inflammation is a final common pathway of chronic kidney disease (CKD), and its progression can be used to effectively gauge the degree of renal dysfunction. Interleukin-1 (IL-1) receptor-associated kinase 4 (IRAK-4) has been reported to be a pivotal molecule for IL-1 receptor- and Toll-like receptor-induced signaling and activation of proinflammatory mediators.


References

1: Kondo M, Tahara A, Hayashi K, Abe M, Inami H, Ishikawa T, Ito H, Tomura Y.
Renoprotective effects of novel interleukin-1 receptor-associated kinase 4
inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats.
Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):909-19. doi:
10.1007/s00210-014-1023-z. Epub 2014 Jul 23. PubMed PMID: 25052043.