RS67506 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532592

CAS#: 168986-61-6 (RS67506 HCl); 160845-97-6 (RS67506).

Description: RS67506 HCl is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.


Chemical Structure

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RS67506 HCl
CAS# 168986-61-6 (RS67506 HCl); 160845-97-6 (RS67506).

Theoretical Analysis

MedKoo Cat#: 532592
Name: RS67506 HCl
CAS#: 168986-61-6 (RS67506 HCl); 160845-97-6 (RS67506).
Chemical Formula: C18H29Cl2N3O4S
Exact Mass: 453.13
Molecular Weight: 454.410
Elemental Analysis: C, 47.58; H, 6.43; Cl, 15.60; N, 9.25; O, 14.08; S, 7.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 168986-61-6 (RS67506 HCl); 160845-97-6 (RS67506).  

Synonym: RS67506 HCl; RS67506 HCl; RS67506; RS 67506; RS-67506.

IUPAC/Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride

InChi Key: GFWKWEHKHLTRRF-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H28ClN3O4S.ClH/c1-26-18-12-16(20)15(19)11-14(18)17(23)4-3-13-5-8-22(9-6-13)10-7-21-27(2,24)25;/h11-13,21H,3-10,20H2,1-2H3;1H

SMILES Code: CS(=O)(NCCN1CCC(CCC(C2=CC(Cl)=C(N)C=C2OC)=O)CC1)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 454.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nagakura Y, Ito H, Kiso T, Naitoh Y, Miyata K. The selective 5-hydroxytryptamine (5-HT)4-receptor agonist RS67506 enhances lower intestinal propulsion in mice. Jpn J Pharmacol. 1997 Jun;74(2):209-12. PubMed PMID: 9243330.