WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530621
Description: HBF-0259 is a novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. HBF-0259 was identified to inhibit HBsAg with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a 50% effective concentration of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.
MedKoo Cat#: 530621
Chemical Formula: C16H12Cl2FN5
Exact Mass: 363.0454
Molecular Weight: 364.2054
Elemental Analysis: C, 52.77; H, 3.32; Cl, 19.47; F, 5.22; N, 19.23
Synonym: HBF-0259; HBF 0259; HBF0259.
IUPAC/Chemical Name: 7-(2-Chloro-6-fluorophenyl)-5-(4-chlorophenyl)-1,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine
InChi Key: BRBZPYDLUUWBCD-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H12Cl2FN5/c17-10-6-4-9(5-7-10)13-8-14(24-16(20-13)21-22-23-24)15-11(18)2-1-3-12(15)19/h1-7,13-14H,8H2,(H,20,21,23)
SMILES Code: ClC1=CC=C(C2N=C3N(NN=N3)C(C4=C(F)C=CC=C4Cl)C2)C=C1
The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals play an important role in suppressing HBV-specific immune response and are only mildly affected by the current small molecule therapies.
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