VU0364739 HCl
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MedKoo CAT#: 530614

CAS#: 1244640-48-9

Description: VU0364739, also known as ML271, is a potent and selective allosteric PLD2 Inhibitor (cellular PLD1, IC50 = 1,500 nM, cellular PLD2, IC50 = 20 nM).


Chemical Structure

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VU0364739 HCl
CAS# 1244640-48-9

Theoretical Analysis

MedKoo Cat#: 530614
Name: VU0364739 HCl
CAS#: 1244640-48-9
Chemical Formula: C26H28ClFN4O2
Exact Mass: 482.1885
Molecular Weight: 482.9844
Elemental Analysis: C, 64.66; H, 5.84; Cl, 7.34; F, 3.93; N, 11.60; O, 6.63

Price and Availability

Size Price Availability Quantity
10.0mg USD 445.0 2 Weeks
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Related CAS #: 1244640-48-9 (HCl)   1244639-78-8 (free)  

Synonym: VU0364739; VU-0364739; VU 0364739; ML-271; ML271, ML 271; VU0364739 HCl; VU0364739 hydrochloride

IUPAC/Chemical Name: N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide hydrochloride

InChi Key: RYLAMDMOILNBKN-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H27FN4O2.ClH/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21;/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33);1H

SMILES Code: O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(C4=CC=CC(F)=C4)CN5)C5=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 482.9844 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Scott SA, O’Reilly MC, Daniels JS, Morrison R, Ptak R, Dawson ES, Tower N, Engers JL, Engers DW, Oguin T, Thomas P, White L, Brown HA, Lindsley CW. Development of a Selective, Allosteric PLD2 Inhibitor. 2012 Apr 5 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Available from http://www.ncbi.nlm.nih.gov/books/NBK143549/PubMed PMID: 23762931.