WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530612
Description: ZINC-3573 is a potent and highly selective MRGPRX2 probe. The MRGPRX2-activating opioids and ZINC-3573 induced intracellular Ca2+ release and degranulation in a human mast cell line. ZINC-3573 activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release. MRGPRX2 is a unique atypical opioid-like receptor important for modulating mast cell degranulation, which can now be specifically modulated with ZINC-3573.
MedKoo Cat#: 530612
Chemical Formula: C18H21N5
Exact Mass: 307.1797
Molecular Weight: 307.401
Elemental Analysis: C, 70.33; H, 6.89; N, 22.78
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 2089389-15-9 (R-isomer) 1378183-16-4 (racemic mixture)
Synonym: ZINC-3573; ZINC 3573; ZINC3573.
IUPAC/Chemical Name: (R)-Dimethyl-[1-(5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl)-pyrrolidin-3-yl]-amine
InChi Key: XKBSPAZCFAIBJL-OAHLLOKOSA-N
InChi Code: InChI=1S/C18H21N5/c1-21(2)15-9-11-22(13-15)18-12-16(14-6-4-3-5-7-14)20-17-8-10-19-23(17)18/h3-8,10,12,15H,9,11,13H2,1-2H3/t15-/m1/s1
SMILES Code: CN(C)[C@H]1CN(C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 307.401 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H,
Carroll FI, Jin J, Shoichet BK, Roth BL. In silico design of novel probes for the
atypical opioid receptor MRGPRX2. Nat Chem Biol. 2017 May;13(5):529-536. doi:
10.1038/nchembio.2334. Epub 2017 Mar 13. PubMed PMID: 28288109; PubMed Central