WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206837
CAS#: 1314891-22-9
Description: TMP195 is a potent and selective class IIa HDAC inhibitor with IC50s of 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.
MedKoo Cat#: 206837
Name: TMP195
CAS#: 1314891-22-9
Chemical Formula: C23H19F3N4O3
Exact Mass: 456.1409
Molecular Weight: 456.4252
Elemental Analysis: C, 60.53; H, 4.20; F, 12.49; N, 12.28; O, 10.52
Synonym: TMP195; TMP-195; TMP 195.
IUPAC/Chemical Name: N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
InChi Key: QTCSXAUJBQZZSN-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H19F3N4O3/c1-22(2,17-12-32-20(28-17)14-7-4-3-5-8-14)13-27-19(31)16-10-6-9-15(11-16)18-29-21(33-30-18)23(24,25)26/h3-12H,13H2,1-2H3,(H,27,31)
SMILES Code: O=C(NCC(C1=COC(C2=CC=CC=C2)=N1)(C)C)C3=CC=CC(C4=NOC(C(F)(F)F)=N4)=C3
1: Cassetta L, Pollard JW. Repolarizing macrophages improves breast cancer
therapy. Cell Res. 2017 Apr 21. doi: 10.1038/cr.2017.63. [Epub ahead of print]
PubMed PMID: 28429765.
2: Targeting Class IIa HDACs May Suppress Breast Tumors and Metastases. Cancer
Discov. 2017 Mar 17. doi: 10.1158/2159-8290.CD-RW2017-053. [Epub ahead of print]
PubMed PMID: 28314719.
3: Guerriero JL, Sotayo A, Ponichtera HE, Castrillon JA, Pourzia AL, Schad S,
Johnson SF, Carrasco RD, Lazo S, Bronson RT, Davis SP, Lobera M, Nolan MA, Letai
A. Class IIa HDAC inhibition reduces breast tumours and metastases through
anti-tumour macrophages. Nature. 2017 Mar 16;543(7645):428-432. doi:
10.1038/nature21409. Epub 2017 Mar 8. PubMed PMID: 28273064.