WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206837

CAS#: 1314891-22-9

Description: TMP195 is a potent and selective class IIa HDAC inhibitor with IC50s of 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.

Price and Availability

Size Price Shipping out time Quantity
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 3450 2 Weeks
2g USD 5450 2 Weeks
5g USD 9650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-24. Prices are subject to change without notice.

TMP195 purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 206837
Name: TMP195
CAS#: 1314891-22-9
Chemical Formula: C23H19F3N4O3
Exact Mass: 456.1409
Molecular Weight: 456.4252
Elemental Analysis: C, 60.53; H, 4.20; F, 12.49; N, 12.28; O, 10.52

Synonym: TMP195; TMP-195; TMP 195.

IUPAC/Chemical Name: N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide


InChi Code: InChI=1S/C23H19F3N4O3/c1-22(2,17-12-32-20(28-17)14-7-4-3-5-8-14)13-27-19(31)16-10-6-9-15(11-16)18-29-21(33-30-18)23(24,25)26/h3-12H,13H2,1-2H3,(H,27,31)

SMILES Code: O=C(NCC(C1=COC(C2=CC=CC=C2)=N1)(C)C)C3=CC=CC(C4=NOC(C(F)(F)F)=N4)=C3

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Cassetta L, Pollard JW. Repolarizing macrophages improves breast cancer
therapy. Cell Res. 2017 Apr 21. doi: 10.1038/cr.2017.63. [Epub ahead of print]
PubMed PMID: 28429765.

2: Targeting Class IIa HDACs May Suppress Breast Tumors and Metastases. Cancer
Discov. 2017 Mar 17. doi: 10.1158/2159-8290.CD-RW2017-053. [Epub ahead of print]
PubMed PMID: 28314719.

3: Guerriero JL, Sotayo A, Ponichtera HE, Castrillon JA, Pourzia AL, Schad S,
Johnson SF, Carrasco RD, Lazo S, Bronson RT, Davis SP, Lobera M, Nolan MA, Letai
A. Class IIa HDAC inhibition reduces breast tumours and metastases through
anti-tumour macrophages. Nature. 2017 Mar 16;543(7645):428-432. doi:
10.1038/nature21409. Epub 2017 Mar 8. PubMed PMID: 28273064.