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MedKoo CAT#: 530611

CAS#: 1422952-82-6

Description: NFEPP, also known as (±)-N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide, is an analgesic opioid chemical, similar in structure to fentanyl, designed in 2016 to avoid the standard negative side effects of opiates, including opioid overdose, by only targeting inflamed tissue. NFEPP has the potential to reduce opioid addiction and dependency, as there is no effect on users who are not actually suffering from pain, as the chemical does not interact with non-inflamed brain tissue.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

NFEPP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530611
CAS#: 1422952-82-6
Chemical Formula: C22H27FN2O
Exact Mass: 354.2107
Molecular Weight: 354.4694
Elemental Analysis: C, 74.55; H, 7.68; F, 5.36; N, 7.90; O, 4.51

Related CAS #: 1422952-83-7 (SS-isomer)   1422952-85-9 (RR-isomer)   1422952-84-8 (3R4S-isomer)   1422952-86-0 (3S4R-isomer)  

Synonym: NFEPP, (±)-N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide.

IUPAC/Chemical Name: N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide


InChi Code: InChI=1S/C22H27FN2O/c1-2-22(26)25(19-11-7-4-8-12-19)21-14-16-24(17-20(21)23)15-13-18-9-5-3-6-10-18/h3-12,20-21H,2,13-17H2,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Spahn V, Del Vecchio G, Labuz D, Rodriguez-Gaztelumendi A, Massaly N, Temp J,
Durmaz V, Sabri P, Reidelbach M, Machelska H, Weber M, Stein C. A nontoxic pain
killer designed by modeling of pathological receptor conformations. Science. 2017
Mar 3;355(6328):966-969. doi: 10.1126/science.aai8636. PubMed PMID: 28254944.