WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530611
Description: NFEPP, also known as (±)-N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide, is an analgesic opioid chemical, similar in structure to fentanyl, designed in 2016 to avoid the standard negative side effects of opiates, including opioid overdose, by only targeting inflamed tissue. NFEPP has the potential to reduce opioid addiction and dependency, as there is no effect on users who are not actually suffering from pain, as the chemical does not interact with non-inflamed brain tissue.
MedKoo Cat#: 530611
Chemical Formula: C22H27FN2O
Exact Mass: 354.2107
Molecular Weight: 354.4694
Elemental Analysis: C, 74.55; H, 7.68; F, 5.36; N, 7.90; O, 4.51
Related CAS #: 1422952-83-7 (SS-isomer) 1422952-85-9 (RR-isomer) 1422952-84-8 (3R4S-isomer) 1422952-86-0 (3S4R-isomer)
Synonym: NFEPP, (±)-N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide.
IUPAC/Chemical Name: N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide
InChi Key: DMCQJJAWMFBPOX-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H27FN2O/c1-2-22(26)25(19-11-7-4-8-12-19)21-14-16-24(17-20(21)23)15-13-18-9-5-3-6-10-18/h3-12,20-21H,2,13-17H2,1H3
SMILES Code: CCC(N(C1C(F)CN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3)=O
1: Spahn V, Del Vecchio G, Labuz D, Rodriguez-Gaztelumendi A, Massaly N, Temp J,
Durmaz V, Sabri P, Reidelbach M, Machelska H, Weber M, Stein C. A nontoxic pain
killer designed by modeling of pathological receptor conformations. Science. 2017
Mar 3;355(6328):966-969. doi: 10.1126/science.aai8636. PubMed PMID: 28254944.