WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407460

CAS#: 924296-39-9

Description: HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.

Price and Availability


USD 3650

USD 4650

USD 6950

HBX 41108 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 407460
Name: HBX-41108
CAS#: 924296-39-9
Chemical Formula: C13H3ClN4O
Exact Mass: 265.9995
Molecular Weight: 266.644
Elemental Analysis: C, 58.56; H, 1.13; Cl, 13.29; N, 21.01; O, 6.00

Related CAS #:  

Synonym: HBX 41108; HBX-41108; HBX41108; HBX 41,108; HBX-41,108; HBX41,108.

IUPAC/Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile


InChi Code: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H

SMILES Code: N#CC1=C(C#N)N=C2C(C(C3=C2C=CC(Cl)=C3)=O)=N1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Nicholson B, Suresh Kumar KG. The multifaceted roles of USP7: new therapeutic
opportunities. Cell Biochem Biophys. 2011 Jun;60(1-2):61-8. doi:
10.1007/s12013-011-9185-5. Review. PubMed PMID: 21468693.

2: Colland F, Formstecher E, Jacq X, Reverdy C, Planquette C, Conrath S, Trouplin
V, Bianchi J, Aushev VN, Camonis J, Calabrese A, Borg-Capra C, Sippl W, Collura
V, Boissy G, Rain JC, Guedat P, Delansorne R, Daviet L. Small-molecule inhibitor
of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol
Cancer Ther. 2009 Aug;8(8):2286-95. doi: 10.1158/1535-7163.MCT-09-0097. Epub 2009
Aug 11. PubMed PMID: 19671755.

3: Lee KW, Cho JG, Kim CM, Kang AY, Kim M, Ahn BY, Chung SS, Lim KH, Baek KH,
Sung JH, Park KS, Park SG. Herpesvirus-associated ubiquitin-specific protease
(HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stability
through its deubiquitinating activity. J Biol Chem. 2013 Nov 15;288(46):32886-96.
doi: 10.1074/jbc.M113.496331. Epub 2013 Sep 26. PubMed PMID: 24072712; PubMed
Central PMCID: PMC3829140.