MDK77754
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MedKoo CAT#: 558271

CAS#: 1599477-75-4

Description: MDK77754, also known as GPR120 Compound A, is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). MDK77754 has CAS#1599477-75-4. For the convenience of communication, we name it as MDK77754. The last 5 digit of CAS# was used in its name.


Chemical Structure

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MDK77754
CAS# 1599477-75-4

Theoretical Analysis

MedKoo Cat#: 558271
Name: MDK77754
CAS#: 1599477-75-4
Chemical Formula: C19H23ClF3NO3
Exact Mass: 405.13
Molecular Weight: 405.842
Elemental Analysis: C, 56.23; H, 5.71; Cl, 8.73; F, 14.04; N, 3.45; O, 11.83

Price and Availability

Size Price Availability Quantity
500mg USD 2250 2 Weeks
1g USD 3650 2 weeks
2g USD 4650 2 weeks
5g USD 6750 2 weeks
Bulk inquiry

Synonym: GPR120 Compound A; MDK77754; MDK-77754; MDK 77754; GPR120 cpdA.

IUPAC/Chemical Name: 3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid

InChi Key: WUJVPELCYCESAP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)

SMILES Code: O=C(O)CC(CC1)CCC21CCN(C3=CC(OC(F)(F)F)=CC=C3Cl)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 405.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R,
Hah N, Chi TJ, Cox JM, Powels MA, Di Salvo J, Sinz C, Watkins SM, Armando AM,
Chung H, Evans RM, Quehenberger O, McNelis J, Bogner-Strauss JG, Olefsky JM. A
Gpr120-selective agonist improves insulin resistance and chronic inflammation in
obese mice. Nat Med. 2014 Aug;20(8):942-7. doi: 10.1038/nm.3614. Epub 2014 Jul 6.
PubMed PMID: 24997608; PubMed Central PMCID: PMC4126875.