ML311
new
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407459

CAS#: 315698-17-0

Description: ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. ML311 Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 will be a useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 1150 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 2450 2 Weeks
1g USD 3250 2 Weeks
2g USD 4950 2 Weeks
5g USD 6450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

ML311, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407459
Name: ML311
CAS#: 315698-17-0
Chemical Formula: C23H24F3N3O
Exact Mass: 415.1871
Molecular Weight: 415.4602
Elemental Analysis: C, 66.49; H, 5.82; F, 13.72; N, 10.11; O, 3.85


Synonym: ML311; ML-311; ML 311; EU-5346; EU 5346; EU5346.

IUPAC/Chemical Name: 7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol

InChi Key: NGAPBLRRJSKIRT-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3

SMILES Code: OC1=C2N=CC=CC2=CC=C1C(N3CCN(CC)CC3)C4=CC=C(C(F)(F)F)C=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Bannister T, Koenig M, He Y, Mishra J, Spicer T, Minond D, Saldanha A, Mercer
BA, Cameron M, Lena R, Carlson N, Richard D, Cardone M, Hodder P. ML311: A Small
Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction
of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. 2012 Apr 16
[updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program
[Internet]. Bethesda (MD): National Center for Biotechnology Information (US);
2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK143557/
PubMed PMID: 23762927.