WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530599

CAS#: 1421227-53-3

Description: WS6 is a beta cell proliferation simulator. WS6 stimulates proliferation of both human beta and alpha cells while maintaining cellular viability and the beta cell differentiated phenotype. WS6 normalized blood glucose and induced concomitant increases in β cell proliferation and β cell number. Affinity pulldown and kinase profiling studies implicate Erb3 binding protein-1 and the IκB kinase pathway in the mechanism of action of WS6. WS6 may help increase human islet mass needed for successful treatment of diabetes.

Price and Availability

Size Price Shipping out time Quantity
1g USD 3250 2 Weeks
2g USD 5250 2 Weeks
5g USD 8950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-27. Prices are subject to change without notice.

WS6, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530599
Name: WS6
CAS#: 1421227-53-3
Chemical Formula: C29H31F3N6O3
Exact Mass: 568.241
Molecular Weight: 568.6012
Elemental Analysis: C, 61.26; H, 5.50; F, 10.02; N, 14.78; O, 8.44

Synonym: WS6; WS-6; WS 6.

IUPAC/Chemical Name: 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide


InChi Code: InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)


Technical Data

White to beige solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Boerner BP, George NM, Mir SU, Sarvetnick NE. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J. 2015;62(4):379-86. doi: 10.1507/endocrj.EJ14-0449. Epub 2015 Mar 11. PubMed PMID: 25739404; PubMed Central PMCID: PMC4876955.

2: Wrighton KC, Castelle CJ, Varaljay VA, Satagopan S, Brown CT, Wilkins MJ, Thomas BC, Sharon I, Williams KH, Tabita FR, Banfield JF. RubisCO of a nucleoside pathway known from Archaea is found in diverse uncultivated phyla in bacteria. ISME J. 2016 Nov;10(11):2702-2714. doi: 10.1038/ismej.2016.53. Epub 2016 May 3. PubMed PMID: 27137126; PubMed Central PMCID: PMC5113843.

3: Shirakawa J, Kulkarni RN. Novel factors modulating human β-cell proliferation. Diabetes Obes Metab. 2016 Sep;18 Suppl 1:71-7. doi: 10.1111/dom.12731. Review. PubMed PMID: 27615134; PubMed Central PMCID: PMC5021183.

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