WS6 | CAS#1421227-53-3 | Beta Cell Proliferation Simulator

WS6
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530599

CAS#: 1421227-53-3

Description: WS6 is a beta cell proliferation simulator. WS6 stimulates proliferation of both human beta and alpha cells while maintaining cellular viability and the beta cell differentiated phenotype. WS6 normalized blood glucose and induced concomitant increases in β cell proliferation and β cell number. Affinity pulldown and kinase profiling studies implicate Erb3 binding protein-1 and the IκB kinase pathway in the mechanism of action of WS6. WS6 may help increase human islet mass needed for successful treatment of diabetes.

Chemical Structure

WS6

CAS# 1421227-53-3

Instruction

Theoretical Analysis

MedKoo Cat#: 530599
Name: WS6
CAS#: 1421227-53-3
Chemical Formula: C29H31F3N6O3
Exact Mass: 568.24
Molecular Weight: 568.601
Elemental Analysis: C, 61.26; H, 5.50; F, 10.02; N, 14.78; O, 8.44

Price and Availability

Size	Price	Availability
100mg	USD 1250	2 Weeks
1g	USD 4250	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: WS6; WS-6; WS 6.

IUPAC/Chemical Name: 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide

InChi Key: FTODTDQFHDJWIQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)

SMILES Code: O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3

Appearance: White to beige solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 568.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Boerner BP, George NM, Mir SU, Sarvetnick NE. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J. 2015;62(4):379-86. doi: 10.1507/endocrj.EJ14-0449. Epub 2015 Mar 11. PubMed PMID: 25739404; PubMed Central PMCID: PMC4876955.

2: Wrighton KC, Castelle CJ, Varaljay VA, Satagopan S, Brown CT, Wilkins MJ, Thomas BC, Sharon I, Williams KH, Tabita FR, Banfield JF. RubisCO of a nucleoside pathway known from Archaea is found in diverse uncultivated phyla in bacteria. ISME J. 2016 Nov;10(11):2702-2714. doi: 10.1038/ismej.2016.53. Epub 2016 May 3. PubMed PMID: 27137126; PubMed Central PMCID: PMC5113843.

3: Shirakawa J, Kulkarni RN. Novel factors modulating human β-cell proliferation. Diabetes Obes Metab. 2016 Sep;18 Suppl 1:71-7. doi: 10.1111/dom.12731. Review. PubMed PMID: 27615134; PubMed Central PMCID: PMC5021183.

4: Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, McNamara P, Glynne R, Wu X, Herman AE, Schultz PG. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. doi: 10.1021/ja309304m. Epub 2013 Jan 25. Erratum in: J Am Chem Soc. 2013 Mar 20;135(11):4573. PubMed PMID: 23330637.

5: Remmas N, Melidis P, Zerva I, Kristoffersen JB, Nikolaki S, Tsiamis G, Ntougias S. Dominance of candidate Saccharibacteria in a membrane bioreactor treating medium age landfill leachate: Effects of organic load on microbial communities, hydrolytic potential and extracellular polymeric substances. Bioresour Technol. 2017 Apr 10;238:48-56. doi: 10.1016/j.biortech.2017.04.019. [Epub ahead of print] PubMed PMID: 28432949.

6: de Gannes V, Bekele I, Dipchansingh D, Wuddivira MN, De Cairies S, Boman M, Hickey WJ. Microbial Community Structure and Function of Soil Following Ecosystem Conversion from Native Forests to Teak Plantation Forests. Front Microbiol. 2016 Dec 9;7:1976. doi: 10.3389/fmicb.2016.01976. eCollection 2016. PubMed PMID: 28018311; PubMed Central PMCID: PMC5145857.

7: Hu P, Tom L, Singh A, Thomas BC, Baker BJ, Piceno YM, Andersen GL, Banfield JF. Genome-Resolved Metagenomic Analysis Reveals Roles for Candidate Phyla and Other Microbial Community Members in Biogeochemical Transformations in Oil Reservoirs. MBio. 2016 Jan 19;7(1):e01669-15. doi: 10.1128/mBio.01669-15. PubMed PMID: 26787827; PubMed Central PMCID: PMC4725000.

8: Dojka MA, Harris JK, Pace NR. Expanding the known diversity and environmental distribution of an uncultured phylogenetic division of bacteria. Appl Environ Microbiol. 2000 Apr;66(4):1617-21. PubMed PMID: 10742250; PubMed Central PMCID: PMC92031.

9: Ye M, Yue T, Yuan Y. Effects of sequential mixed cultures of Wickerhamomyces anomalus and Saccharomyces cerevisiae on apple cider fermentation. FEMS Yeast Res. 2014 Sep;14(6):873-82. doi: 10.1111/1567-1364.12175. Epub 2014 Jul 2. PubMed PMID: 24931623.

10: Cardinali-Rezende J, Pereira ZL, Sanz JL, Chartone-Souza E, Nascimento AM. Bacterial and archaeal phylogenetic diversity associated with swine sludge from an anaerobic treatment lagoon. World J Microbiol Biotechnol. 2012 Nov;28(11):3187-95. doi: 10.1007/s11274-012-1129-8. Epub 2012 Jul 25. PubMed PMID: 22828793.

11: Briée C, Moreira D, López-García P. Archaeal and bacterial community composition of sediment and plankton from a suboxic freshwater pond. Res Microbiol. 2007 Apr;158(3):213-27. Epub 2007 Jan 27. PubMed PMID: 17346937.

12: Wu GF, Wu XC, Xuan XD, Zhou XP. Evaluation of nutrient limitation in aquatic ecosystems with nitrogen fixing bacteria. J Environ Sci (China). 2006;18(3):537-42. PubMed PMID: 17294653.

13: Huber JA, Butterfield DA, Baross JA. Bacterial diversity in a subseafloor habitat following a deep-sea volcanic eruption. FEMS Microbiol Ecol. 2003 Apr 1;43(3):393-409. doi: 10.1111/j.1574-6941.2003.tb01080.x. PubMed PMID: 19719671.

14: Dojka MA, Hugenholtz P, Haack SK, Pace NR. Microbial diversity in a hydrocarbon- and chlorinated-solvent-contaminated aquifer undergoing intrinsic bioremediation. Appl Environ Microbiol. 1998 Oct;64(10):3869-77. PubMed PMID: 9758812; PubMed Central PMCID: PMC106571.

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