WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530590
Description: MTC420 is a anti-tuberculosis agent. MTC420 displays acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM) and favourable pharmacokinetic and toxicological profiles.
MedKoo Cat#: 530590
Chemical Formula: C20H16F4N2O
Exact Mass: 376.1199
Molecular Weight: 376.3546
Elemental Analysis: C, 63.83; H, 4.29; F, 20.19; N, 7.44; O, 4.25
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: MTC420; MTC-420; MTC 420.
IUPAC/Chemical Name: 2-(4-(3,3-difluoropyrrolidin-1-yl)phenyl)-5,7-difluoro-3-methylquinolin-4(1H)-one
InChi Key: FFUXCAUWEZSJRC-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H16F4N2O/c1-11-18(25-16-9-13(21)8-15(22)17(16)19(11)27)12-2-4-14(5-3-12)26-7-6-20(23,24)10-26/h2-5,8-9H,6-7,10H2,1H3,(H,25,27)
SMILES Code: FC1=C2C(NC(C3=CC=C(N4CCC(F)(F)C4)C=C3)=C(C)C2=O)=CC(F)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 376.3546 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Hong WD, Gibbons PD, Leung SC, Amewu R, Stocks PA, Stachulski AV, Horta PC,
Cristiano ML, Shone AE, Moss D, Ardrey A, Sharma R, Warman AJ, Bedingfield PT,
Fisher NE, Aljayyoussi G, Mead S, Caws M, Berry NG, Ward SA, Biagini GA, O'Neill
PM, Nixon GL. Rational Design, Synthesis and Biological Evaluation of
Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium
tuberculosis. J Med Chem. 2017 Mar 17. doi: 10.1021/acs.jmedchem.6b01718. [Epub
ahead of print] PubMed PMID: 28304162.
In 2014, tuberculosis (TB) globally infected 9.6 million people, resulting in an estimated 1.5 million deaths.1 With the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) TB, the need for new drug treatments targeting the disease has never been greater.