WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407443
Description: FM-381 is a Chemical Probe For JAK3 and JAK3 specific reversible covalent inhibitor.
MedKoo Cat#: 407443
Chemical Formula: C24H24N6O2
Exact Mass: 428.1961
Molecular Weight: 428.496
Elemental Analysis: C, 67.27; H, 5.65; N, 19.61; O, 7.47
Synonym: FM-381; FM 381; FM381.
IUPAC/Chemical Name: (E)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
InChi Key: GJMZWYLOARVASY-NTCAYCPXSA-N
InChi Code: InChI=1S/C24H24N6O2/c1-29(2)24(31)15(13-25)12-17-8-9-20(32-17)23-28-19-14-27-22-18(10-11-26-22)21(19)30(23)16-6-4-3-5-7-16/h8-12,14,16H,3-7H2,1-2H3,(H,26,27)/b15-12+
SMILES Code: O=C(N(C)C)/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5
AK kinases are effectors of the JAK-STAT signaling pathway, which is triggered by ligand binding to a cognate receptor resulting in activation of JAK by phosphorylation of key tyrosine residues within the catalytic domain. After activation, tyrosine resides in the receptor intracellular region are also phosphorylated which triggers recruitment and phosphorylation of the principal downstream effectors, the STATs. Phosphorylated STATs dimerize and translocate to the nucleus where they initiate transcription of specific responsive genes