MX69
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MedKoo CAT#: 407438

CAS#: 1005264-47-0

Description: MX69 is a Dual Inhibitor of MDM2 and XIAP for Cancer Treatment.


Chemical Structure

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MX69
CAS# 1005264-47-0

Theoretical Analysis

MedKoo Cat#: 407438
Name: MX69
CAS#: 1005264-47-0
Chemical Formula: C27H26N2O4S
Exact Mass: 474.16
Molecular Weight: 474.575
Elemental Analysis: C, 68.33; H, 5.52; N, 5.90; O, 13.48; S, 6.76

Price and Availability

Size Price Availability Quantity
100mg USD 1050
200mg USD 1750
500mg USD 2450
1g USD 3250
2g USD 4850
5g USD 8250
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Synonym: MX69; MX-69; MX 69.

IUPAC/Chemical Name: 4-(8-(N-(2,3-dimethylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid

InChi Key: LAISWEODQAOXGJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H26N2O4S/c1-16-5-3-8-24(17(16)2)29-34(32,33)20-13-14-25-23(15-20)21-6-4-7-22(21)26(28-25)18-9-11-19(12-10-18)27(30)31/h3-6,8-15,21-22,26,28-29H,7H2,1-2H3,(H,30,31)

SMILES Code: O=S(C1=CC2=C(NC(C3=CC=C(C(O)=O)C=C3)C4C2C=CC4)C=C1)(NC5=C(C)C(C)=CC=C5)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
In vitro activity: MX69 exhibited a significant cytotoxic effect on both ALL and NB lines, particularly those lines with MDM2 overexpression and a WT-p53 phenotype (Figure 6A and B). Figure 6C shows representative photomicrographs indicating cell growth inhibition and/or cell death in NB-1691 cells following treatment by MX69. Reference: Cancer Cell. 2016 Oct 10;30(4):623-636. https://pubmed.ncbi.nlm.nih.gov/27666947/
In vivo activity: Here, this study administered MX69 intraperitoneally to high-fat diet-induced obesity (DIO) wild type C57BL/6 mice and found that MX69 could promote the body weight and white adipose tissue weight of DIO mice. Moreover, MX69 had no effects on glucose tolerance and insulin sensitivity in DIO mice. And MX69 treatment decreased the size of adipocytes and fat deposition in adipose tissue and inhibited 3T3-L1 preadipocytes differentiation. Mechanistically, MX69 inhibited the protein levels of MDM2 and the mRNA levels of genes related to adipogenesis and differentiation. Reference: Biochem Biophys Res Commun. 2022 Oct 15;625:9-15. https://pubmed.ncbi.nlm.nih.gov/35944364/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 97.5 205.45
Ethanol 41.0 86.39

Preparing Stock Solutions

The following data is based on the product molecular weight 474.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Faruq O, Zhao D, Shrestha M, Vecchione A, Zacksenhaus E, Chang H. Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma. Cancers (Basel). 2022 Mar 21;14(6):1592. doi: 10.3390/cancers14061592. PMID: 35326742; PMCID: PMC8945937. 2. Gu L, Zhang H, Liu T, Zhou S, Du Y, Xiong J, Yi S, Qu CK, Fu H, Zhou M. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636. doi: 10.1016/j.ccell.2016.08.015. Epub 2016 Sep 22. PMID: 27666947; PMCID: PMC5079537. 3. Zhao W, Yang J, Xie X, Li C, Zhang W, Chen E, Guo Y, Yan L, Fang F, Yao H, Liu X. A MDM2 inhibitor MX69 inhibits adipocytes adipogenesis and differentiation. Biochem Biophys Res Commun. 2022 Oct 15;625:9-15. doi: 10.1016/j.bbrc.2022.07.115. Epub 2022 Aug 2. PMID: 35944364.
In vitro protocol: 1. Faruq O, Zhao D, Shrestha M, Vecchione A, Zacksenhaus E, Chang H. Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma. Cancers (Basel). 2022 Mar 21;14(6):1592. doi: 10.3390/cancers14061592. PMID: 35326742; PMCID: PMC8945937. 2. Gu L, Zhang H, Liu T, Zhou S, Du Y, Xiong J, Yi S, Qu CK, Fu H, Zhou M. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636. doi: 10.1016/j.ccell.2016.08.015. Epub 2016 Sep 22. PMID: 27666947; PMCID: PMC5079537.
In vivo protocol: 1. Zhao W, Yang J, Xie X, Li C, Zhang W, Chen E, Guo Y, Yan L, Fang F, Yao H, Liu X. A MDM2 inhibitor MX69 inhibits adipocytes adipogenesis and differentiation. Biochem Biophys Res Commun. 2022 Oct 15;625:9-15. doi: 10.1016/j.bbrc.2022.07.115. Epub 2022 Aug 2. PMID: 35944364.

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1: Gu L, Zhang H, Liu T, Zhou S, Du Y, Xiong J, Yi S, Qu CK, Fu H, Zhou M.
Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell.
2016 Oct 10;30(4):623-636. doi: 10.1016/j.ccell.2016.08.015. Epub 2016 Sep 22.
PubMed PMID: 27666947; PubMed Central PMCID: PMC5079537.