GJ-103 free acid
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MedKoo CAT#: 530575

CAS#: 1459687-89-8 (free acid)

Description: GJ-103 is an active analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 750 2 Weeks
200mg USD 1150 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
2g USD 4650 2 Weeks
5g USD 6750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

GJ-103 free acid, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530575
Name: GJ-103 free acid
CAS#: 1459687-89-8 (free acid)
Chemical Formula: C16H14N4O3S
Exact Mass: 342.0787
Molecular Weight: 342.373
Elemental Analysis: C, 56.13; H, 4.12; N, 16.36; O, 14.02; S, 9.36


Related CAS #: 1459687-96-7 (sodium)   1459687-89-8 (free acid)  

Synonym: GJ-103 free acid; GJ103; GJ 103; GJ-103.

IUPAC/Chemical Name: 2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid

InChi Key: GBVQSAZHPCDBDY-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14N4O3S/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22/h2-9H,10H2,1H3,(H,21,22)

SMILES Code: O=C(O)CSC1=NN=C(C2=NC=CC=C2)N1C3=CC=CC(OC)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H,
Gatti RA. A new series of small molecular weight compounds induce read through of
all three types of nonsense mutations in the ATM gene. Mol Ther. 2013
Sep;21(9):1653-60. doi: 10.1038/mt.2013.150. Epub 2013 Jun 18. PubMed PMID:
23774824; PubMed Central PMCID: PMC3776636.

2: Lavin MF. Generating SM(a)RTer compounds for translation termination
suppression in A-T and other genetic disorders. Mol Ther. 2013 Sep;21(9):1650-2.
doi: 10.1038/mt.2013.177. PubMed PMID: 24008619; PubMed Central PMCID:
PMC3776641.