WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407436

CAS#: 945526-43-2

Description: ISCK03 is a potent c-kit inhibitor. ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 650 2 Weeks
200mg USD 1050 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
2g USD 4350 2 Weeks
5g USD 7250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-23. Prices are subject to change without notice.

ISCK03, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 407436
Name: ISCK03
CAS#: 945526-43-2
Chemical Formula: C19H21N3O2S
Exact Mass: 355.1354
Molecular Weight: 355.456
Elemental Analysis: C, 64.20; H, 5.96; N, 11.82; O, 9.00; S, 9.02

Synonym: ISCK03, ISCK-03, ISCK 03.

IUPAC/Chemical Name: [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide


InChi Code: InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-6-17(7-5-15)22(25(23)24)18-10-8-16(9-11-18)21-13-12-20-14-21/h4-14,25H,1-3H3

SMILES Code: O=S(N(C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(N3C=CN=C3)C=C2)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Na YJ, Baek HS, Ahn SM, Shin HJ, Chang IS, Hwang JS.
[4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits
SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin
production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep
1;74(5):780-6. Epub 2007 Jun 14. PubMed PMID: 17658483.

2: Kamlah F, Hänze J, Arenz A, Seay U, Hasan D, Juricko J, Bischoff B, Gottschald
OR, Fournier C, Taucher-Scholz G, Scholz M, Seeger W, Engenhart-Cabillic R, Rose
F. Comparison of the effects of carbon ion and photon irradiation on the
angiogenic response in human lung adenocarcinoma cells. Int J Radiat Oncol Biol
Phys. 2011 Aug 1;80(5):1541-9. doi: 10.1016/j.ijrobp.2011.03.033. Epub 2011 May
27. PubMed PMID: 21621345.

3: Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, Yamazaki T. Long
noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation
of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7.
PubMed PMID: 25928165; PubMed Central PMCID: PMC4423487.