WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206818

CAS#: 2060571-02-8

Description: Inavolisib, also known as GDC-0077, is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and results in the inhibition of growth and survival of PI3K-overexpressing tumor cells.

Chemical Structure

CAS# 2060571-02-8

Theoretical Analysis

MedKoo Cat#: 206818
Name: GDC-0077
CAS#: 2060571-02-8
Chemical Formula: C18H19F2N5O4
Exact Mass: 407.14
Molecular Weight: 407.378
Elemental Analysis: C, 53.07; H, 4.70; F, 9.33; N, 17.19; O, 15.71

Price and Availability

Size Price Availability Quantity
1mg USD 90 Ready to ship
5mg USD 250 Ready to ship
10mg USD 450 Ready to ship
25mg USD 750 Ready to ship
50mg USD 1250 Ready to ship
100mg USD 2150 Ready to ship
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Synonym: GDC-0077; GDC 0077; GDC0077; Inavolisib; RG6114; RG 6114; RG-6114

IUPAC/Chemical Name: (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide


InChi Code: InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1

SMILES Code: C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: PI3Kα
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 110.0 245.47

Preparing Stock Solutions

The following data is based on the product molecular weight 407.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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