CB-1158
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206811

CAS#: 1345810-21-0

Description: CB-1158, also known as INCB01158, is a potent arginase inhibitor. CB-1158 has the potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role. CB-1158 may also have the ability to combine with other immuno-oncology therapies that target T-cell activation, such as CTLA-4 and PD-1 antibodies.


Price and Availability

Size
Price

5mg
USD 150
50mg
USD 850
Size
Price

10mg
USD 250
1g
Ask price
Size
Price

25mg
USD 450

CB-1158, purity > 97%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 2.0g may be 1 month


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206811
Name: CB-1158
CAS#: 1345810-21-0
Chemical Formula: C18H27BCl2N2O4
Exact Mass: 416.1441
Molecular Weight: 417.134
Elemental Analysis: C, 51.83; H, 6.52; B, 2.59; Cl, 17.00; N, 6.72; O, 15.34


Synonym: CB-1158, CB 1158, CB1158, INCB01158, INCB 01158, INCB-01158.

IUPAC/Chemical Name: 2-amino-6-borono-2-(1-(2,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid

InChi Key: ISYBHIALKUAHGV-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H27BCl2N2O4/c20-15-4-3-13(16(21)11-15)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25)

SMILES Code: ClC1=CC(Cl)=CC=C1CN2CCC(C(N)(CCCCB(O)O)C(O)=O)CC2


Technical Data

Appearance:
White to off-white solid powder

Purity:
>97% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in water

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490