Iberdomide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528831

CAS#: 1323403-33-3

Description: Iberdomide, also known as CC-220, is potentially for the treatment of systemic lupus erythematosus. Iberdomide significantly reduced Ikaros and Aiolos protein levels in B cells, T cells and monocytes. In SLE PBMC cultures, iberdomide inhibited anti-dsDNA and anti-phospholipid autoantibody production (IC50 ≈10 nM).

Chemical Structure

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Iberdomide
CAS# 1323403-33-3
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 528831
Name: Iberdomide
CAS#: 1323403-33-3
Chemical Formula: C25H27N3O5
Exact Mass: 449.1951
Molecular Weight: 449.5
Elemental Analysis: C, 66.80; H, 6.05; N, 9.35; O, 17.80

Size Price Shipping out time Quantity
5mg USD 260 2 Weeks
100mg USD 1150 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3650 2 Weeks
2g USD 5650 2 Weeks
5g USD 11450 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-03-05. Prices are subject to change without notice.

Iberdomide, purity > 98%, is in stock. Current shipping out time is about 2-3 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received

Synonym: CC-220; CC220; CC 220; Iberdomide.

IUPAC/Chemical Name: (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

InChi Key: IXZOHGPZAQLIBH-NRFANRHFSA-N

InChi Code: InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1

SMILES Code: O=C([C@@H](N(CC1=C2C=CC=C1OCC3=CC=C(CN4CCOCC4)C=C3)C2=O)CC5)NC5=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 449.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: Skinner C, Gaddie J, Palmer KN. Comparison of intravenous AH 5158 (ibidomide)
and propranolol in asthma. Br Med J. 1975 Apr 12;2(5962):59-61. PubMed PMID:
236806; PubMed Central PMCID: PMC1673027.

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Iberdomide

5mg / USD 260