WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 528518
CAS#: 447410-57-3
Description: SB-756050 is a G protein-coupled bile acid receptor 1 (GPBAR1) agonist potentially for the treatment of type 2 diabetes.
MedKoo Cat#: 528518
Name: SB-756050
CAS#: 447410-57-3
Chemical Formula: C21H28N2O8S2
Exact Mass: 500.1287
Molecular Weight: 500.581
Elemental Analysis: C, 50.39; H, 5.64; N, 5.60; O, 25.57; S, 12.81
Synonym: SB-756050; SB 756050; SB756050
IUPAC/Chemical Name: 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane
InChi Key: GJUFPAZNBPFNRI-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H28N2O8S2/c1-28-18-8-6-16(14-20(18)30-3)32(24,25)22-10-5-11-23(13-12-22)33(26,27)17-7-9-19(29-2)21(15-17)31-4/h6-9,14-15H,5,10-13H2,1-4H3
SMILES Code: O=S(N1CCN(S(=O)(C2=CC=C(OC)C(OC)=C2)=O)CCC1)(C3=CC=C(OC)C(OC)=C3)=O
1: Hodge RJ, Lin J, Vasist Johnson LS, Gould EP, Bowers GD, Nunez DJ; SB-756050 Project Team.. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013 Jul;2(3):213-22. doi: 10.1002/cpdd.34. Epub 2013 May 14. PubMed PMID: 27121782.