NGB2904 HCl
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MedKoo CAT#: 532347

CAS#: 189060-98-8 (HCl)

Description: NGB2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM)

Chemical Structure

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NGB2904 HCl
CAS# 189060-98-8 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 532347
Name: NGB2904 HCl
CAS#: 189060-98-8 (HCl)
Chemical Formula: C28H30Cl3N3O
Exact Mass: 493.17
Molecular Weight: 530.918
Elemental Analysis: C, 63.34; H, 5.70; Cl, 20.03; N, 7.91; O, 3.01

Price and Availability

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5mg USD 210
10mg USD 385
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Related CAS #: 189060-98-8 (HCl)   189061-11-8 (free base)    

Synonym: NGB2904; NGB 2904; NGB-2904.

IUPAC/Chemical Name: N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamide hydrochloride

InChi Key: PFIWYJNBKGCVFM-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H

SMILES Code: O=C(C1=CC(CC2=C3C=CC=C2)=C3C=C1)NCCCCN4CCN(C5=CC=CC(Cl)=C5Cl)CC4.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 530.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hussein N, Amawi H, Karthikeyan C, Hall FS, Mittal R, Trivedi P, Ashby CR Jr, Tiwari AK. The dopamine D(3) receptor antagonists PG01037, NGB2904, SB277011A, and U99194 reverse ABCG2 transporter-mediated drug resistance in cancer cell lines. Cancer Lett. 2017 Mar 18. pii: S0304-3835(17)30179-9. doi: 10.1016/j.canlet.2017.03.015. [Epub ahead of print] PubMed PMID: 28323029.