Itriglumide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528823

CAS#: 201605-51-8

Description: Itriglumide is a CCK2 receptor antagonist potentially for the treatment of peptic ulcers, dyspepsia, and gastroesophageal reflux disease (GERD).

Chemical Structure

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Itriglumide
CAS# 201605-51-8
Instruction

Theoretical Analysis

MedKoo Cat#: 528823
Name: Itriglumide
CAS#: 201605-51-8
Chemical Formula: C33H38N2O4
Exact Mass: 526.28
Molecular Weight: 526.677
Elemental Analysis: C, 75.26; H, 7.27; N, 5.32; O, 12.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CR-2945; CR2945; CR 2945

IUPAC/Chemical Name: (R)-5-((2,4-dimethyl-6-(8-azaspiro[4.5]decane-8-carbonyl)phenyl)amino)-3-(naphthalen-1-yl)-5-oxopentanoic acid

InChi Key: MFOOVZCXWVAWOV-RUZDIDTESA-N

InChi Code: InChI=1S/C33H38N2O4/c1-22-18-23(2)31(28(19-22)32(39)35-16-14-33(15-17-35)12-5-6-13-33)34-29(36)20-25(21-30(37)38)27-11-7-9-24-8-3-4-10-26(24)27/h3-4,7-11,18-19,25H,5-6,12-17,20-21H2,1-2H3,(H,34,36)(H,37,38)/t25-/m1/s1

SMILES Code: O=C(O)C[C@H](C1=C2C=CC=CC2=CC=C1)CC(NC3=C(C)C=C(C)C=C3C(N(CC4)CCC54CCCC5)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 526.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ekström J, Cevik Aras H. Parasympathetic non-adrenergic, non-cholinergic transmission in rat parotid glands: effects of cholecystokinin-A and -B receptor antagonists on the secretory response. Regul Pept. 2008 Feb 7;146(1-3):278-84. Epub 2007 Oct 22. PubMed PMID: 18006087.

2: Danzer M, Jocic M, Samberger C, Painsipp E, Bock E, Pabst MA, Crailsheim K, Schicho R, Lippe IT, Holzer P. Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G403-11. Epub 2003 Oct 30. PubMed PMID: 14592947.

3: Cevik Aras H, Ekström J. Pentagastrin-induced protein synthesis in the parotid gland of the anaesthetized rat, and its dependence on CCK-A and -B receptors and nitric oxide generation. Exp Physiol. 2006 Jul;91(4):673-9. Epub 2006 Mar 23. PubMed PMID: 16556659.

4: Aras HC, Ekström J. Cholecystokinin- and gastrin-induced protein and amylase secretion from the parotid gland of the anaesthetized rat. Regul Pept. 2006 May 15;134(2-3):89-96. Epub 2006 Mar 2. PubMed PMID: 16515811.

5: Lehmann F, Hildebrand P, Beglinger C. New molecular targets for treatment of peptic ulcer disease. Drugs. 2003;63(17):1785-97. Review. PubMed PMID: 12921485.