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MedKoo CAT#: 532343

CAS#: 104869-26-3

Description: NF157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). NF157 displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2 , P2X2, P2X3, P2X4 and P2X7 receptors. NF157 also inhibits NAD+-induced activation of human granulocytes.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 350 2 Weeks
50mg USD 1280 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-22. Prices are subject to change without notice.

NF157, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 532343
Name: NF157
CAS#: 104869-26-3
Chemical Formula: C49H34F2N6O23S6
Exact Mass: 1303.9968
Molecular Weight: 1305.19
Elemental Analysis: C, 45.09; H, 2.63; F, 2.91; N, 6.44; O, 28.19; S, 14.74

Synonym: NF157; NF 157; NF-157.

IUPAC/Chemical Name: 8-[[4-fluoro-3-[[3-[[3-[[2-fluoro-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid


InChi Code: InChI=1S/C49H34F2N6O23S6/c50-33-9-7-25(47(60)54-35-11-13-39(83(69,70)71)31-19-29(81(63,64)65)21-41(43(31)35)85(75,76)77)17-37(33)56-45(58)23-3-1-5-27(15-23)52-49(62)53-28-6-2-4-24(16-28)46(59)57-38-18-26(8-10-34(38)51)48(61)55-36-12-14-40(84(72,73)74)32-20-30(82(66,67)68)22-42(44(32)36)86(78,79)80/h1-22H,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)

SMILES Code: O=S(C1=C2C(NC(C3=CC=C(F)C(NC(C4=CC=CC(NC(NC5=CC=CC(C(NC6=CC(C(NC7=C8C(S(=O)(O)=O)=CC(S(=O)(O)=O)=CC8=C(S(=O)(O)=O)C=C7)=O)=CC=C6F)=O)=C5)=O)=C4)=O)=C3)=O)=CC=C(S(=O)(O)=O)C2=CC(S(=O)(O)=O)=C1)(O)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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7: Djerada Z, Peyret H, Dukic S, Millart H. Extracellular NAADP affords cardioprotection against ischemia and reperfusion injury and involves the P2Y11-like receptor. Biochem Biophys Res Commun. 2013 May 10;434(3):428-33. doi: 10.1016/j.bbrc.2013.03.089. Epub 2013 Apr 9. PubMed PMID: 23583195.

8: Sakaki H, Tsukimoto M, Harada H, Moriyama Y, Kojima S. Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor. PLoS One. 2013;8(4):e59778. doi: 10.1371/journal.pone.0059778. Epub 2013 Apr 5. PubMed PMID: 23577075; PubMed Central PMCID: PMC3618444.

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12: Ben Yebdri F, Kukulski F, Tremblay A, Sévigny J. Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion. Eur J Immunol. 2009 Oct;39(10):2885-94. doi: 10.1002/eji.200939347. PubMed PMID: 19735076; PubMed Central PMCID: PMC5140286.

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14: Moreschi I, Bruzzone S, Bodrato N, Usai C, Guida L, Nicholas RA, Kassack MU, Zocchi E, De Flora A. NAADP+ is an agonist of the human P2Y11 purinergic receptor. Cell Calcium. 2008 Apr;43(4):344-55. Epub 2007 Aug 17. PubMed PMID: 17707504.

15: Sundqvist M. Developmental changes of purinergic control of intestinal motor activity during metamorphosis in the African clawed frog, Xenopus laevis. Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1916-25. Epub 2007 Feb 1. PubMed PMID: 17272661.

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