WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528817

CAS#: 189362-06-9

Description: K-134 is a PDE3 inhibitor potentially for the treatment of anti-thrombotic and anti-hyperplastic activities.

Price and Availability




K-134 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 528817
Name: K-134
CAS#: 189362-06-9
Chemical Formula: C22H29N3O4
Exact Mass:
Molecular Weight: 399.491
Elemental Analysis: C, 66.14; H, 7.32; N, 10.52; O, 16.02

Synonym: K-134; OPC-33509; K134; OPC33509; K 134; OPC 33509

IUPAC/Chemical Name: 1-cyclopropyl-1-((1R,2R)-2-hydroxycyclohexyl)-3-(3-((2-oxo-1,2-dihydroquinolin-6-yl)oxy)propyl)urea


InChi Code: InChI=1S/C22H29N3O4/c26-20-5-2-1-4-19(20)25(16-7-8-16)22(28)23-12-3-13-29-17-9-10-18-15(14-17)6-11-21(27)24-18/h6,9-11,14,16,19-20,26H,1-5,7-8,12-13H2,(H,23,28)(H,24,27)/t19-,20-/m1/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


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2: Yoshida H, Ashikawa Y, Itoh S, Nakagawa T, Asanuma A, Tanabe S, Inoue Y, Hidaka H. K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model. PLoS One. 2012;7(10):e46432. doi: 10.1371/journal.pone.0046432. Epub 2012 Oct 23. PubMed PMID: 23110051; PubMed Central PMCID: PMC3479105.

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