WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530558
CAS#: 4499-01-8 (sodium)
Description: PSB-1011 is a competitive inhibitor of the rat P2X2 receptor with a Ki value of 79 nM. PSB-1011 exhibited a competitive mechanism of action (pA(2) 7.49). It was >100-fold selective versus P2X4, P2X7, and several investigated P2Y receptor subtypes (P2Y(2,4,6,12)); selectivity versus P2X1 and P2X3 receptors was moderate (>5-fold). PSB-1011 was >13-fold more potent at the homomeric P2X2 than at the heteromeric P2X2/3 receptor.
MedKoo Cat#: 530558
Name: PSB-1011 sodium
CAS#: 4499-01-8 (sodium)
Chemical Formula: C23H12Cl2N6Na2O8S2
Exact Mass:
Molecular Weight: 681.3825
Elemental Analysis: C, 40.54; H, 1.78; Cl, 10.41; N, 12.33; Na, 6.75; O, 18.78; S, 9.41
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Related CAS #: 4499-01-8 (sodium) 13324-20-4 (free acid)
Synonym: PSB-1011; PSB 1011; PSB1011.
IUPAC/Chemical Name: disodium 1-amino-4-[3-(4,6-dichloro[1,3,5]triazine-2-ylamino)-4-sulfophenylamino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
InChi Key: DHHMYWVFMSHEIP-UHFFFAOYSA-L
InChi Code: InChI=1S/C23H14Cl2N6O8S2.2Na/c24-21-29-22(25)31-23(30-21)28-12-7-9(5-6-14(12)40(34,35)36)27-13-8-15(41(37,38)39)18(26)17-16(13)19(32)10-3-1-2-4-11(10)20(17)33;;/h1-8,27H,26H2,(H,34,35,36)(H,37,38,39)(H,28,29,30,31);;/q;2*+1/p-2
SMILES Code: O=S(C(C(N)=C1C2=O)=CC(NC3=CC=C(S(=O)([O-])=O)C(NC4=NC(Cl)=NC(Cl)=N4)=C3)=C1C(C5=C2C=CC=C5)=O)([O-])=O.[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 681.3825 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hausmann R, Schmalzing G. P2X1 and P2X2 receptors in the central nervous
system as possible drug targets. CNS Neurol Disord Drug Targets. 2012
Sep;11(6):675-86. Review. PubMed PMID: 22963438.
2: Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, Müller CE.
Discovery of potent competitive antagonists and positive modulators of the P2X2
receptor. J Med Chem. 2011 Feb 10;54(3):817-30. Epub 2011 Jan 5. PubMed PMID:
21207957.
