PSB-1011 sodium

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MedKoo CAT#: 530558

CAS#: 4499-01-8 (sodium)

Description: PSB-1011 is a competitive inhibitor of the rat P2X2 receptor with a Ki value of 79 nM. PSB-1011 exhibited a competitive mechanism of action (pA(2) 7.49). It was >100-fold selective versus P2X4, P2X7, and several investigated P2Y receptor subtypes (P2Y(2,4,6,12)); selectivity versus P2X1 and P2X3 receptors was moderate (>5-fold). PSB-1011 was >13-fold more potent at the homomeric P2X2 than at the heteromeric P2X2/3 receptor.


Chemical Structure

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PSB-1011 sodium
CAS# 4499-01-8 (sodium)

Theoretical Analysis

MedKoo Cat#: 530558
Name: PSB-1011 sodium
CAS#: 4499-01-8 (sodium)
Chemical Formula: C23H12Cl2N6Na2O8S2
Exact Mass: 0.00
Molecular Weight: 681.383
Elemental Analysis: C, 40.54; H, 1.78; Cl, 10.41; N, 12.33; Na, 6.75; O, 18.78; S, 9.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 4499-01-8 (sodium)   13324-20-4 (free acid)    

Synonym: PSB-1011; PSB 1011; PSB1011.

IUPAC/Chemical Name: disodium 1-amino-4-[3-(4,6-dichloro[1,3,5]triazine-2-ylamino)-4-sulfophenylamino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate

InChi Key: DHHMYWVFMSHEIP-UHFFFAOYSA-L

InChi Code: InChI=1S/C23H14Cl2N6O8S2.2Na/c24-21-29-22(25)31-23(30-21)28-12-7-9(5-6-14(12)40(34,35)36)27-13-8-15(41(37,38)39)18(26)17-16(13)19(32)10-3-1-2-4-11(10)20(17)33;;/h1-8,27H,26H2,(H,34,35,36)(H,37,38,39)(H,28,29,30,31);;/q;2*+1/p-2

SMILES Code: O=S(C(C(N)=C1C2=O)=CC(NC3=CC=C(S(=O)([O-])=O)C(NC4=NC(Cl)=NC(Cl)=N4)=C3)=C1C(C5=C2C=CC=C5)=O)([O-])=O.[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 681.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hausmann R, Schmalzing G. P2X1 and P2X2 receptors in the central nervous
system as possible drug targets. CNS Neurol Disord Drug Targets. 2012
Sep;11(6):675-86. Review. PubMed PMID: 22963438.


2: Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, Müller CE.
Discovery of potent competitive antagonists and positive modulators of the P2X2
receptor. J Med Chem. 2011 Feb 10;54(3):817-30. Epub 2011 Jan 5. PubMed PMID:
21207957.