WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530553

CAS#: 1079821-35-4

Description: NCG21 is a GPR120 agonist. NCG21 showed potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120 system. NCG21 potently activated ERK, intracellular calcium responses and GLP-1 secretion in murine enteroendocrine STC-1 cells that express GPR120 endogenously. Moreover, administration of NCG21 into the mouse colon caused an increase in plasma GLP-1 levels.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2021-01-19. Prices are subject to change without notice.

NCG21 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530553
Name: NCG21
CAS#: 1079821-35-4
Chemical Formula: C23H24N2O3
Exact Mass: 376.1787
Molecular Weight: 376.456
Elemental Analysis: C, 73.38; H, 6.43; N, 7.44; O, 12.75

Synonym: NCG21; NCG-21; NCG 21.

IUPAC/Chemical Name: 4-{4-[2-(Phenyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-butyric acid


InChi Code: InChI=1S/C23H24N2O3/c26-23(27)11-6-7-19-12-14-21(15-13-19)28-18-17-25(20-8-2-1-3-9-20)22-10-4-5-16-24-22/h1-5,8-10,12-16H,6-7,11,17-18H2,(H,26,27)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

GPR120 is a G protein-coupled receptor expressed preferentially in the intestinal tract and adipose tissue, that has been implicated in mediating free fatty acid-stimulated glucagon-like peptide-1 (GLP-1) secretion.


1: Sun Q, Hirasawa A, Hara T, Kimura I, Adachi T, Awaji T, Ishiguro M, Suzuki T,
Miyata N, Tsujimoto G. Structure-activity relationships of GPR120 agonists based
on a docking simulation. Mol Pharmacol. 2010 Nov;78(5):804-10. doi:
10.1124/mol.110.066324. Epub 2010 Aug 4. PubMed PMID: 20685848.