MRS3558

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532303

CAS#: 793695-40-6

Description: MRS3558 is an A3 adenosine receptors Agonist.

Chemical Structure

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MRS3558
CAS# 793695-40-6
Instruction

Theoretical Analysis

MedKoo Cat#: 532303
Name: MRS3558
CAS#: 793695-40-6
Chemical Formula: C20H20Cl2N6O3
Exact Mass: 462.10
Molecular Weight: 463.320
Elemental Analysis: C, 51.85; H, 4.35; Cl, 15.30; N, 18.14; O, 10.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MRS3558; MRS 3558; MRS-3558.

IUPAC/Chemical Name: (1S,2R,3S,4R,5S)-4-[2-chloro-6-[(3-chlorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide

InChi Key: WBUOCDGSBFEIOR-DDDALXFXSA-N

InChi Code: InChI=1S/C20H20Cl2N6O3/c1-23-18(31)20-7-11(20)13(14(29)15(20)30)28-8-24-12-16(25-19(22)26-17(12)28)27(2)10-5-3-4-9(21)6-10/h3-6,8,11,13-15,29-30H,7H2,1-2H3,(H,23,31)/t11-,13-,14+,15+,20+/m1/s1

SMILES Code: O=C([C@]12[C@@H](O)[C@@H](O)[C@H](N3C=NC4=C(N(C5=CC=CC(Cl)=C5)C)N=C(Cl)N=C34)[C@@]1([H])C2)NC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 463.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hu H, Lu W, Zhang M, Zhang X, Argall AJ, Patel S, Lee GE, Kim YC, Jacobson KA, Laties AM, Mitchell CH. Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo. Exp Eye Res. 2010 Sep;91(3):425-32. doi: 10.1016/j.exer.2010.06.017. Epub 2010 Jul 1. PubMed PMID: 20599962; PubMed Central PMCID: PMC2941978.

2: Matot I, Einav S, Weiniger CF, Pearl RG, Abramovitch R, Joshi BV, Jacobson KA. Lung injury after in vivo reperfusion: outcome at 27 hours after reperfusion. Anesthesiology. 2008 Aug;109(2):269-78. doi: 10.1097/ALN.0b013e31817f5b90. PubMed PMID: 18648236; PubMed Central PMCID: PMC2688693.

3: Gao ZG, Jacobson KA. Translocation of arrestin induced by human A(3) adenosine receptor ligands in an engineered cell line: comparison with G protein-dependent pathways. Pharmacol Res. 2008 Apr;57(4):303-11. doi: 10.1016/j.phrs.2008.02.008. Epub 2008 Mar 8. PubMed PMID: 18424164; PubMed Central PMCID: PMC2409065.

4: Matot I, Weiniger CF, Zeira E, Galun E, Joshi BV, Jacobson KA. A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion. Crit Care. 2006;10(2):R65. PubMed PMID: 16623960; PubMed Central PMCID: PMC1550918.

5: Joshi BV, Jacobson KA. Purine derivatives as ligands for A3 adenosine receptors. Curr Top Med Chem. 2005;5(13):1275-95. Review. PubMed PMID: 16305531.